Publications by authors named "Bibi Rahima"
Nasal application of native cholera toxin (nCT) as a mucosal adjuvant has potential toxicity for the CNS through binding to GM1 gangliosides in the olfactory nerves. Although mutants of cholera toxin (mCTs) have been developed that show mucosal adjuvant activity without toxicity, it still remains unclear whether these mCTs will induce CNS damage. To help overcome these concerns, in this study we created new double mutant CTs (dmCTs) that have two amino acid substitutions in the ADP-ribosyltransferase active center (E112K) and COOH-terminal KDEL (E112K/KDEV or E112K/KDGL).
View Article and Find Full Text PDFPrognostic significance of perineural invasion in oral and oropharyngeal carcinoma.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
April 2004
Article Synopsis
- The study aimed to assess the occurrence and importance of perineural invasion (PNI) in patients with squamous cell carcinoma (SCC) in the oral cavity and oropharynx.
- Out of 101 patients evaluated, PNI was found in 25.7% and was linked to worse outcomes, including local and regional recurrence, as well as distant metastasis.
- The findings revealed that patients with PNI had a significantly lower 5-year survival rate (56.6%) compared to those without PNI (94.6%), indicating that PNI is a critical predictor of prognosis in these patients.
Background: Carcinomas of the oral cavity present a high risk for neck metastases that decrease the disease control and survival.
Methods: A total of 106 patients with squamous cell carcinoma of the oral cavity who had metastatic neck nodes were studied. The impact of neck metastasis and treatment modalities on outcome was assessed.