Effect of adenosine and adenosine-5'-triphosphate on atrioventricular conduction in patients.

This study was carried out to further elucidate the effects of adenosine and adenosine-5'-triphosphate (ATP) on atrioventricular (AV) conduction in patients. Adenosine (0.24 mg/kg) and ATP (0.

Two-dimensional echocardiographic recognition of a pacing catheter perforation of the interventricular septum.

A case of a pacing catheter perforation of the interventricular septum is presented here. The entire catheter length was visualized by two-dimensional real-time echocardiography utilizing the subcostal approach; the catheter was seen entering the left ventricle through the high interventricular septum.

Electrophysiologic properties of intravenous Tenormine in man.

The acute electrophysiologic effects of intravenous Tenormine (0.1 mg/kg body weight), a new cardioselective beta-adrenoreceptor blocking drug, were studied in 18 subjects with estimated normal impulse formation and conduction. The most significant (P less than 0.

Chronic juvenile AV nodal dysfunction associated with mitral valve prolapse.

The prevalence of atrioventricular (AV) conduction disturbances amongst patients with mitral valve prolapse is higher than may be expected by chance, thus implying the existence of a true association. The main clinical and electrophysiologic findings in 4 patients with mitral valve prolapse showing chronic AV conduction disturbances are presented. Supra-His localization, mild and variable degree of impairment, regression upon Atropine administration, apparent absence of progression, are common features of these disturbances.

Ileum-like congenital elongation of the proximal descending aorta.

A case of extraordinary congenital elongation of the proximal descending aorta giving origin to multiple aortic loops, packed in the left-postero-superior mediastinum, is presented. Clinical findings, that is, mid-late systolic ejection murmur, a delayed peak of the femoral pulse, blood pressure in the legs slightly lower than in the arms, were considered noncontributory from the diagnostic point of view, since they may also be present in mild aortic coarctation and in aortic kinking. Chest roentgenogram and fluoroscopy showing 2 pulsating masses protruding to the left of the proximal descending aorta suggested the presence of a more complex aortic malformation.

Electrophysiological properties of intravenous metoprolol in man.

Electrophysiological changes produced by intravenous (0.1 mg/kg) metoprolol, a new selective beta 1-blocking agent devoid of intrinsic activity, were studied in 16 subjects with estimated normal impulse formation and conduction. The most important effects were sinus bradycardia, mild increase of sinoatrial conduction time, depression of intranodal conduction, and prolongation of AV node refractory periods.

Electrophysiologic evaluation of intravenous verapamil in man.

The acute electrophysiological effects of intravenous verapamil (0.15 mg/kg body weight) were studied in 21 subjects with estimated normal impulse formation and conduction. Significant effects were sinus cycle shortening, depression of intranodal conduction and prolongation of AV node refractory periods.

Electrophysiologic properties of intravenous oxprenolol in man.

Electrophysiologic modifications produced by intravenous administration of 0.1 mg/Kg Oxprenolol were studied in 16 subjects with estimated normal impulse formation and conduction. Significant effects were sinus bradycardia, mild increase of sino-atrial conduction time, depression of intranodal conduction and prolongation of A-V node refractory periods.

Intra-His bundle block in acute myocardial infarction. Report of two cases.

Two patients with acute intra-His bundle block, both secondary to myocardial infarction, are described. The diagnosis of the block was proved by means of His bundle recordings during the phase of complete atrio-ventricular (A-V) block. Two His bundle potentials, one (H) following each A wave and the other (H') preceding each QRS complex, were detected.

Effects of prindolol on impulse formation and conduction in man.

Electrophysiologic changes produced by intravenous administration of 0.6 mg Prindolol were studied in 16 subjects with normal impulse formation and conduction. The most important changes were: sinus bradycardia, prolongation of atrial refractory periods, depression of intranodal conduction and prolongation of A-V node refractory periods.

Electrophysiologic evaluation of intravenous bunaphtine in man.

The acute electrophysiologic effects of intravenous Bunaphtine 1,5 mg/kg body weight, a new antiarrhythmic drug, were studied in 19 subjects with estimated normal impulse formation and conduction. Significant effects were sinus bradycardia, prolongation of atrial refractory periods, depression of intranodal and infranodal conduction and prolongation of His-Purkinje system refractory periods. These properties are compared with those of amiodarone and quinidine and form the basis for a correct use of Bunaphtine in the management of arrhythmias.

[Coronary spasm and acute coronary insufficiency (author's transly)].

A series of cases illustrating a spectrum of acute coronary episodes associated with transient subepicardial injury, namely the variant form of angina, angina intermedia with electrocardiographic changes similar to those of the variant angina, acute myocardial infarction complicated by variant angina with electrocardiographic changes localized to the infarcted area, acute myocardial infarction preceded and followed by variant angina, is presented. The role of a coronary spasm as a common mechanism of the above mentioned episodes is postulated. Coronarographic demonstration of this mechanism is produced.