Publications by authors named "Biaoxiong Wang"
PLK3 facilitates replication of swine influenza virus by phosphorylating viral NP protein.
Emerg Microbes Infect
December 2023
Article Synopsis
- Swine H1N1/2009 influenza is a contagious disease affecting pigs, significantly impacting both pig farming and human health.
- The study analyzed how swine genes respond to the virus in newborn pig trachea cells and identified 166 genes that are differentially expressed.
- A key focus was on polo-like kinase 3 (PLK3), which was found to be upregulated during infection and plays a crucial role in enhancing viral replication by interacting with the virus's nucleoprotein and promoting its phosphorylation and assembly.
The genome of Influenza A virus (IAV) transcribes and replicates in the nucleus of cells and the viral ribonucleoprotein (vRNP) complex plays an important role in viral replication. As a major component of the vRNP complex, the polymerase basic protein 2 (PB2) is translocated to the nucleus via its nuclear localization signals mediated by the importins. Herein, it was identified proliferating cell nuclear antigen (PCNA) as an inhibitor of nuclear import of PB2 and subsequent viral replication.
View Article and Find Full Text PDFThe prevalence of swine pandemic H1N1/2009 influenza A virus (SIV-H1N1/2009) in pigs has the potential to generate novel reassortant viruses, posing a great threat to human health. Cellular microRNAs (miRNAs) have been proven as promising small molecules for regulating influenza A virus replication by directly targeting viral genomic RNA. In this study, we predicted potential (ssc-, swine) miRNAs targeting the genomic RNA of SIV-H1N1/2009 by RegRNA 2.
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