Publications by authors named "Biao-Liang Wu"
Article Synopsis
- Diabetic foot ulcers (DFU) are a major cause of disability in diabetic patients, and this study aimed to uncover the gene changes associated with DFU.
- Researchers analyzed gene expression data from different DFU patients, identifying 238 upregulated and 207 downregulated genes in ulcer patients compared to those without ulcers, along with 74 upregulated and 28 downregulated genes in healed versus unhealed samples.
- Functional enrichment analysis revealed that key biological processes involved include immune responses and cell migration, with particular focus on interleukin (IL)-1B's elevated expression in ulcer patients, highlighting the significance of immune cell interactions in DFU healing.
Background: Long noncoding RNA MALAT1 is closely related to diabetes and kidney diseases and is expected to be a new target for the diagnosis and treatment of diabetic nephropathy.
Objective: This study aimed to explore the circulating expression level and significance of lncRNA Malat1 in patients with type 2 diabetes mellitus (T2DM) and diabetic kidney disease (DKD).
Methods: Quantitative real-time PCR (qPCR) was conducted to assess the expression of lncRNA Malat1 in 20 T2DM patients, 27 DKD patients, and 14 healthy controls, and then, the clinical significance was analyzed.