AIDS-Associated Infection with Thoracic Spinal Cord Involvement Leading to Paraplegia: A Case Report and Literature Review.

Background: is a common opportunistic infection in patients with acquired immune deficiency syndrome (AIDS) in South China. Spinal cord abscesses caused by are exceptionally rare and present with non-specific symptoms, which may result in delayed diagnosis and heightened adverse prognoses.

Case Presentation: We report a case of a spinal cord abscess in a 30-year-old patient with AIDS that was caused by infection.

Minor Effects of Warming on Soil Microbial Diversity, Richness and Community Structure.

Climate warming has caused widespread global concern. However, how warming affects soil microbial diversity, richness, and community structure on a global scale remains poorly understood. Here we conduct a meta-analysis of 945 observations from 100 publications by collecting relevant data.

Altered precipitation affects soil enzyme activity related to nitrogen and phosphorous but not carbon cycling: A meta-analysis.

Altered precipitation significantly influences soil function in terrestrial ecosystems. As a bioindicator of soil function, soil extracellular enzyme activity (EEA) plays a crucial role in mediating ecosystem responses to altered precipitation. However, the global patterns and regulatory mechanisms of altered precipitation impacts on soil EEAs remain unclear.

Function and structure of broadly neutralizing antibodies against SARS-CoV-2 Omicron variants isolated from prototype strain infected convalescents.

Background: The ongoing emergence of evolving SARS-CoV-2 variants poses great threaten to the efficacy of authorized monoclonal antibody-based passive immunization or treatments. Developing potent broadly neutralizing antibodies (bNabs) against SARS-CoV-2 and elucidating their potential evolutionary pathways are essential for battling the coronavirus disease 2019 (COVID-19) pandemic.

Methods: Broadly neutralizing antibodies were isolated using single cell sorting from three COVID-19 convalescents infected with prototype SARS-CoV-2 strain.

Effect of blood purification combined with antibiotics on CC-16 and SP-D levels and prognosis in patients with severe acute pancreatitis complicated by acute respiratory distress syndrome.

Objective: To investigate the effects of continuous blood purification (CBP) combined with antibiotics on pulmonary surfactant protein D (SP-D), Clara cell protein-16 (CC-16), and prognosis in patients with severe acute pancreatitis (SAP) complicated by acute respiratory distress syndrome (ARDS).

Methods: A total of 128 patients with SAP and ARDS treated at Fudan University Shanghai Cancer Center from June 2021 to June 2023 were enrolled. Patients were divided into two groups: a control group (n=64) receiving routine treatment (gastrointestinal decompression, somatostatin administration, nutritional support, correction of water-electrolyte imbalance, and microcirculation improvement) and an observation group (n=64) treated with CBP combined with antibiotics.

Large emissions of CO and CH due to active-layer warming in Arctic tundra.

Climate warming may accelerate decomposition of Arctic soil carbon, but few controlled experiments have manipulated the entire active layer. To determine surface-atmosphere fluxes of carbon dioxide and methane under anticipated end-of-century warming, here we used heating rods to warm (by 3.8 °C) to the depth of permafrost in polygonal tundra in Utqiaġvik (formerly Barrow), Alaska and measured fluxes over two growing seasons.

Climate, plant and microorganisms jointly influence soil organic matter fractions in temperate grasslands.

Soil organic carbon (SOC) plays a critical role in mitigating climate change. Conceptualizing SOC into particulate organic carbon (POC) and mineral-associated organic carbon (MAOC) helps us more accurately predict the responses of organic carbon, with varying chemical composition, molecular size, and degree of association with soil minerals, to environmental changes. To assess the controlling factors of particulate organic carbon (POC) and mineral-associated organic carbon (MAOC), plant and soil samples were collected from 54 temperate grassland sites in Northern China, and the impacts of climate, plants, soil properties and microorganisms on POC and MAOC contents were analyzed.

Mycorrhizal dominance influences tree species richness and richness-biomass relationship in China's forests.

Mycorrhizal associations drive plant community diversity and ecosystem functions. Arbuscular mycorrhiza (AM) and ectomycorrhiza (EcM) are two widespread mycorrhizal types and are thought to differentially affect plant diversity and productivity by nutrient acquisition and plant-soil feedback. However, it remains unclear how the mixture of two mycorrhizal types influences tree diversity, forest biomass, and their relationship at large spatial scales.

FKBP5 Regulates the Osteogenesis of Human Adipose-derived Mesenchymal Stem Cells.

Objective: Human adipose-derived stem cells (ASCs) have shown considerable potential for tissue regeneration. FK506 binding protein (FKBP) 5 is a cochaperone of several proteins. The purpose of this work was to explore the function of FKBP5 in ASC osteogenesis.

Neuregulin 4 attenuates pancreatic β-cell apoptosis induced by lipotoxicity via activating mTOR-mediated autophagy.

Neuregulin 4 (Nrg4) is a brown fat-enriched endocrine factor that ameliorates lipid metabolism disorders. Autophagy is critical for pancreatic β-cell to counteract lipotoxicity-induced apoptosis. This study aimed at exploring whether Nrg4 attenuates lipotoxicity-induced β-cell apoptosis by regulating autophagy.

Photobiomodulation therapy at 650 nm enhances osteogenic differentiation of osteoporotic bone marrow mesenchymal stem cells through modulating autophagy.

Background: Photobiomodulatiom therapy (PBMT) has biostimulatory effects on bone marrow mesenchymal stem cells (BMSCs), which takes a pivotal role in maintaining bone mass and avoiding osteoporosis (OP). Autophagy is an important regulator for cell survival and homeostasis. Previous researchers found that BMSCs derived from osteoporotic rats (OP-BMSCs) were with the feature of reduced osteogenic differentiation and autophagy dysfunction.

Exogenous allyl isothiocyanate mitigates the drought stress by regulating the stomatal characteristic, antioxidant capacity, and glucosinolate metabolism in pakchoi.

Drought is a global issue that has increasingly garnered worldwide attention. Glucosinolates (GSLs) are significant sulfur-containing compounds in cruciferous plants such as pakchoi (Brassica rapa L. ssp.

Positive soil priming effects are the rule at a global scale.

Priming effects of soil organic matter decomposition are critical to determine carbon budget and turnover in soil. Yet, the overall direction and intensity of soil priming remains under debate. A second-order meta-analysis was performed with 9296-paired observations from 363 primary studies to determine the intensity and general direction of priming effects depending on the compound type, nutrient availability, and ecosystem type.

Direct antiglobulin (Coombs) test in HIV-positive Talaromycosis marneffei patients.

Talaromycosis marneffei (T.M) is the primary opportunistic infection of AIDS patients, and its morbidity and mortality are extremely high. To further clarify the disease characteristics of patients and provide a solid basis for in-depth exploration of their pathogenic mechanisms, we retrospectively summarized and analyzed their clinical data.

Neuregulin 4 Attenuates Podocyte Injury and Proteinuria in Part by Activating AMPK/mTOR-Mediated Autophagy in Mice.

In this study, we investigate the effect of neuregulin 4 (NRG4) on podocyte damage in a mouse model of diabetic nephropathy (DN) and we elucidate the underlying molecular mechanisms. In vivo experiments were conducted using a C57BL/6 mouse model of DN to determine the effect of NRG4 on proteinuria and podocyte injury, and in vitro experiments were performed with conditionally immortalized mouse podocytes treated with high glucose and NRG4 to assess the protective effects of NRG4 on podocyte injury. Autophagy-related protein levels and related signaling pathways were evaluated both in vivo and in vitro.

Colonization ability and uniformity of resources and environmental factors determine biological homogenization of soil protists in human land-use systems.

Humans have substantially transformed the global land surface, resulting in the decline in variation in biotic communities across scales, a phenomenon known as "biological homogenization." However, different biota are affected by biological homogenization to varying degrees, but this variation and the underlying mechanisms remain little studied, particularly in soil systems. To address this topic, we used metabarcoding to investigate the biogeography of soil protists and their prey/hosts (prokaryotes, fungi, and meso- and macrofauna) in three human land-use ecosystem types (farmlands, residential areas, and parks) and natural forest ecosystems across subtropical and temperate regions in China.

Mineralization and microbial utilization of poly(lactic acid) microplastic in soil.

The current carbon dioxide (CO) evolution-based standard method for determining biodegradable microplastics (MPs) degradation neglects its priming effect on soil organic matter decomposition, which misestimates their biodegradability. Here, a C natural abundance method was used to estimate the mineralization of poly(lactic acid) (PLA) MP in various agricultural soils, and to trace its utilization in different microbial groups. In alkaline soils, the PLA-derived CO emissions increased with increasing soil carbon/nitrogen (C/N) ratios, and the mineralization of PLA MP concentrations ranged from 3-33 %, whereas the CO evolution method probably over- or under-estimated the mineralization of PLA in alkaline soils with different soil C/N ratios.

Permafrost carbon cycle and its dynamics on the Tibetan Plateau.

Our knowledge on permafrost carbon (C) cycle is crucial for understanding its feedback to climate warming and developing nature-based solutions for mitigating climate change. To understand the characteristics of permafrost C cycle on the Tibetan Plateau, the largest alpine permafrost region around the world, we summarized recent advances including the stocks and fluxes of permafrost C and their responses to thawing, and depicted permafrost C dynamics within this century. We find that this alpine permafrost region stores approximately 14.

Global turnover of soil mineral-associated and particulate organic carbon.

Soil organic carbon (SOC) persistence is predominantly governed by mineral protection, consequently, soil mineral-associated (MAOC) and particulate organic carbon (POC) turnovers have different impacts on the vulnerability of SOC to climate change. Here, we generate the global MAOC and POC maps using 8341 observations and then infer the turnover times of MAOC and POC by a data-model integration approach. Global MAOC and POC storages are Pg C (mean with 5% and 95% quantiles) and Pg C, while global mean MAOC and POC turnover times are yr and yr in the top meter, respectively.