Serum galectin-3 can help distinguish lupus nephritis from systemic lupus erythematosus and is also correlated with the degree of renal damage in lupus nephritis.

Lupus nephritis (LN) constitutes a substantial contributor to morbidity and mortality in systemic lupus erythematosus (SLE). The monitoring of renal function in patients with LN is associated with improved prognostication. The objective of this study was to evaluate the clinical utility of serum galectin-3 (Gal-3) levels in differentiating LN from SLE.

High-accuracy spatial prediction of soil pollutants and their speciation in strong human-affected areas.

Strong human activities greatly challenge the high-accuracy spatial prediction of soil pollutants and their speciation. This study first determined three auxiliary variables of soil total arsenic (TA) in a typical strong human-affected area, namely in-situ portable X-ray fluorescence (PXRF) TA calibrated by robust geographically weighted regression (RGWR), atmospheric deposition information simulated by atmospheric diffusion model (AERMOD), and land-use types. Then, robust residual cokriging with the above three auxiliary variables (RRCoK-RCPXRF/AD/LUT) was proposed to spatially predict soil TA.

Urine PLA2R Antibody Detection in Hazard Stratification of PLA2R-Associated Membranous Nephropathy.

Context.—: M-type phospholipase A2 receptor (PLA2R) is the major autoantigen of membranous nephropathy (MN). As the specific antibodies of MN, the correlation between serum PLA2R antibody (sPLA2R-Ab) levels and PLA2R-associated MN (PMN) risk stratification is still controversial.

β'-COP mediated loading of PPARγ into trophoblast-derived extracellular vesicles.

Fetal growth restriction (FGR) is characterized by impaired fetal growth and dysregulated lipid metabolism. Extracellular vesicles (EVs) have been proved playing a crucial role in transporting biomolecules from the mother to the fetus. However, the mechanisms underlying cargo sorting and loading into trophoblastic EVs remain elusive.

Logically Activatable Nanoreporter for Multiplexed Time-Phased Imaging Assessment of Hepatic Ischemia-Reperfusion Injury and Systemic Inflammation.

Hepatic ischemia-reperfusion injury (HIRI) and induced systemic inflammation is a time-dependent multistage process which poses a risk of causing direct hepatic dysfunction and multiorgan failure. Real-time in situ comprehensive visualization assessment is important and scarce for imaging-guided therapeutic interventions and timely efficacy evaluation. Here, a logically activatable nanoreporter (termed QD@IR783-TK-FITC) is developed for time-phase imaging quantification of HIRI and induced systemic inflammation.

Vascular endothelial growth factor pathway's influence on bevacizumab efficacy in metastatic colorectal cancer treatment.

In this article, an article published in the , which focuses on whether the expression of programmed death-ligand 1 (PD-L1) affects the effectiveness of chemotherapy regimens, including bevacizumab, in treating patients with colorectal cancer (CRC). Through neutralization of vascular endothelial growth factor (VEGF), bevacizumab inhibits tumor angiogenesis, impairing neovascularization and thereby depriving the tumor of essential nutrients and oxygen. Conversely, PD-L1 binding to VEGF receptor 2 promotes angiogenesis, supporting tumor vasculature.

Review of Progress in the Application of Polytetrafluoroethylene-Based Battery Separators.

Batteries have broad application prospects in the aerospace, military, automotive, and medical fields. The performance of the battery separator, a key component of rechargeable batteries, is inextricably linked to the quality of the batteries. The polytetrafluoroethylene (PTFE)-based membrane, in addition to PTFE's intrinsic properties of corrosion resistance and high temperature resistance, also possesses characteristics such as high porosity and high strength, making it an ideal substrate for the separator in current high-performance batteries, such as fuel cells (FC), all-vanadium redox liquid current batteries (VRBs), solid-state batteries (SSBs), and lithium-ion batteries (LIBs).

The joint associations of ambient air pollutants and weather factors with mortality: Evidence from a national time-stratified case-crossover study in China.

Background: People in daily life are usually exposed to multiple environmental factors, but few studies have evaluated the joint health impacts of ambient air pollutants and weather factors.

Objectives: To investigate the joint associations of short-term exposures to ambient air pollutants and weather factors with mortality and estimate the mortality burden attributable to these multiple environmental exposures in China.

Methods: We collected individual death information from six provinces (Guangdong, Yunnan, Hunan, Zhejiang, Tibet and Jilin) in China during 2013 to 2018, and applied a time-stratified case-crossover study design to estimate the joint associations of air pollutants [PM (particulate matter with an aerodynamic diameter ≤2.

A Novel ANG-BSA/BCNU/ICG MNPs Integrated for Targeting Therapy of Glioblastoma.

Purpose: Develop an albumin nanoparticle-based nanoprobe for targeted glioblastoma (GBM) diagnosis and treatment, utilizing Angopep-2 for low-density lipoprotein receptor-related protein (LRP) targeting.

Methods: Combined albumin-coated superparamagnetic iron oxide (SPIO), Carmustine (BCNU), and indocyanine green (ICG). Assessed morphology, size, Zeta potential, fluorescence, and drug encapsulation.

M D-VAE: Self-Supervised Probabilistic Temporal- Spatial Latent Representation Learning for Unsupervised Industrial Operational Applications Under Missing Value Interference.

Due to sensor malfunctions and data transmission corruptions, the industrial process data collected commonly contain missing values. It poses a significant challenge for data-driven approaches in aggregating temporal-spatial correlations that reflect dependencies across both variables and times, which makes it difficult to directly carry out downstream industrial operational applications. In this study, a self-supervised representation learning model is proposed to extract probabilistic temporal-spatial latent variables (LVs) from sequential data under missing value interference.

RNAs associated with oxidative stress and apoptosis show anticancer effects of Flos Sophorae flavonoids extract on human hepatoma cells.

Flos Sophorae, a traditional Chinese medicinal herb and health tea, consists of the dried flowers and buds of the Sophora japonica L. (Leguminosae). This study assesses the in vitro anticancer efficacy of Flos Sophorae flower extract (FSFE) against the human hepatocarcinoma cell line HepG2, juxtaposed with its effects on normal human liver L02 cells.

Projecting future minimum mortality temperature in China.

Minimum mortality temperature (MMT) increases with global warming due to climate adaptation, which is crucial for the precise assessment of mortality burden attributed to climate change. Nevertheless, forecasting future MMT poses a challenge given the unavailability of future mortality data. Here, we attempted to develop a novel approach to project future MMT.

Facile Synthesis and Characterization of Fluorescent Polystyrene Nanospheres for Homogeneous Light-Initiated Chemiluminescence Immunoassay.

Homogeneous light-initiated chemiluminescence technology (LICA) is widely used in clinical diagnostics due to the advantages of high sensitivity, minimal reagent usage, and no need for washing. Luminescent microspheres receive singlet oxygen emitted by photosensitive microspheres to generate optical signals. Therefore,O-initiated luminescent nanospheres are crucial, but there are few reports on the preparation of O-initiated luminescent nanospheres.

Sandwich Therapy with Radionuclide Combined with Intralesional Injections Based on Differences in the Spatial Structure Components of Keloids.

Background: Complications such as ulceration, depigmentation, and recurrence limit the use of intralesional injections and brachytherapy in keloid treatment. We designed a modified "sandwich" therapy based on the spatial distribution of keloid components to reduce the incidence of these complications.

Methods: First, we analyzed the spatial distribution pattern of scar tissue through single-cell sequencing analysis, ultrasound, and pathology.

Levodopa therapy affects brain functional network dynamics in Parkinson's disease.

Levodopa (L-dopa) therapy is the most effective pharmacological treatment for motor symptoms of Parkinson's disease (PD). However, its effect on brain functional network dynamics is still unclear. Here, we recruited 26 PD patients and 24 healthy controls, and acquired their resting-state functional MRI data before (PD-OFF) and after (PD-ON) receiving 400 mg L-dopa.