Publications by authors named "Bianza Tinotenda Mbavha"

Pharmacogenomic testing may be used to improve treatment outcomes and reduce the frequency of adverse drug reactions (ADRs). Population specific, targeted pharmacogenetics (PGx) panel-based testing methods enable sensitive, accurate and economical implementation of precision medicine. We evaluated the analytical performance of the GenoPharm® custom open array platform which evaluates 120 SNPs across 46 pharmacogenes.

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Article Synopsis
  • * A study involving 40 breast cancer patients in Zimbabwe found that many had genetic variants (polymorphisms) in CYP2D6 that affect drug metabolism, leading to lower endoxifen levels.
  • * Results showed that 55% of participants had endoxifen concentrations below the therapeutic threshold, highlighting a significant relationship between CYP2D6 genetic variations and endoxifen levels (with specific statistical significance).
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