Publications by authors named "Bianka Souza dos Santos"
Adipose tissue derived mesenchymal stem cell transplantation in the treatment of ischemia/reperfusion induced acute kidney injury in rats. Application route and therapeutic window1.
Betânia Souza Monteiro Bianka Souza Dos Santos Bruna Lopes de Almeida Emy Hiura Wagner Alexey Back Fiorio
Acta Cir Bras
November 2018
Purpose: To evaluate renal repair in rats who had renal infarction induced by the obstruction of blood flow in the renal artery and were treated with transplantation of adipose tissue derived mesenchymal stem cell.
Methods: 16-week-old Wistar rats (n=72) were used, submitted to celiotomy and had of the renal artery and vein clipped for 24 hours. The animals were randomly assigned to 10 experimental homogeneous groups, corresponding to the treatments with phosphate-buffered saline (PBS) or adipose tissue derived mesenchymal stem cell (ADSC), duration of application (24 or 48 hours), and site of transplantation (lateral vein of the tail or intrarenal).
Article Synopsis
- The study aimed to assess how mesenchymal stem cells (MSCs) from specific mice, combined with platelet-rich plasma (PRP), affect the healing of severe bone defects in other mice.
- The experimental setup involved creating a 6.0mm cranial defect in twenty-four adult mice, with one group receiving treatment (MSC + PRP) and the other serving as a control.
- Results showed that the treated group experienced improved angiogenesis and bone repair compared to the control, indicating that MSCs and PRP positively influence bone healing.