Intravitreal bevacizumab at 4-month intervals for prevention of macular edema after plaque radiotherapy of uveal melanoma.

Purpose: To evaluate the efficacy of intravitreal bevacizumab for prevention of macular edema after plaque radiotherapy of uveal melanoma.

Design: Retrospective, single-center, nonrandomized, interventional comparative study.

Participants: Patients with uveal melanoma treated with plaque radiotherapy were divided into 2 groups: a bevacizumab group and a control group.

Ciliary body and choroidal pseudomelanoma from ultrasonographic imaging of hypermature cataract in 20 cases.

Purpose: To describe a series of 20 patients with opaque media, referred with uveal melanoma, but subsequently found to have pseudomelanoma from oblique imaging of hypermature cataract on ultrasonography.

Design: Case series.

Participants: Twenty patients.

Genomic profile of 320 uveal melanoma cases: chromosome 8p-loss and metastatic outcome.

Purpose: Uveal melanoma (UM) was a fatal malignancy in 40% to 50% of cases. The aim of this study is to evaluate the independent contributions of chromosome 1, 3, 6, and 8 abnormalities for prognostication of metastasis, and to define multichromosome copy number aberration (CNA) signatures that can be used to evaluate risk.

Methods: A series of 320 UM were analyzed for chromosome 1, 3, 6, and 8 abnormalities using whole genome single-nucleotide polymorphism arrays.

Single-agent, minimal dose, minimal exposure intraarterial chemotherapy for retinoblastoma in a 4-month-old infant.

Purpose: To document minimal dose and minimal exposure of chemotherapy for unilateral retinoblastoma.

Methods: A 4-month-old infant developed leukocoria in the right eye and was found to have unilateral sporadic retinoblastoma.

Results: The right eye was classified as Group D retinoblastoma, with a single large tumor, moderate subretinal seeding, and total retinal detachment.

Safety of pars plana vitrectomy in eyes with plaque-irradiated posterior uveal melanoma.

Objective: To determine the long-term safety of pars plana vitrectomy (PPV) in eyes with plaque-irradiated posterior uveal melanoma.

Methods: In this retrospective case series, patients with plaque-irradiated posterior uveal melanoma subsequently underwent PPV for vitreous hemorrhage. The main outcome measures are the rates of intraocular melanoma dissemination, extrascleral extension of melanoma, local melanoma recurrence, and systemic melanoma metastasis after PPV.

Retinoblastoma frontiers with intravenous, intra-arterial, periocular, and intravitreal chemotherapy.

In this report, we explore retinoblastoma diagnostic accuracy and review chemotherapy alternatives for retinoblastoma using intravenous, intra-arterial, periocular, and intravitreal routes. A review of 2775 patients referred for management of retinoblastoma, disclosed 78% with confirmed retinoblastoma and 22% with simulating lesions, termed pseudoretinoblastomas. Children ≤2 years old showed leading pseudoretinoblastomas of persistent fetal vasculature, Coats disease, and vitreous haemorrhage, whereas those >5 years showed simulators of Coats, toxocariasis, and familial exudative vitreoretinopathy.

Iris melanoma management with iodine-125 plaque radiotherapy in 144 patients: impact of melanoma-related glaucoma on outcomes.

Purpose: To evaluate the outcomes of iris melanoma managed with plaque radiotherapy on the basis of the initial presence or absence of glaucoma.

Design: Retrospective, comparative case series.

Participants: A total of 144 patients.

Acute exudative paraneoplastic polymorphous vitelliform maculopathy in five cases.

Background And Objective: To evaluate clinical features, course, and outcome of patients with acute exudative paraneoplastic polymorphous vitelliform maculopathy (AEPPVM).

Patients And Methods: Retrospective case series of 5 patients.

Results: There were 3 males and 2 females, with a median age of 74 years.

Pearls and pitfalls of intraarterial chemotherapy for retinoblastoma.

Retinoblastoma is a deadly eye cancer in children, leading to death in 50%-70% of children in undeveloped nations who are diagnosed with it. This malignancy is the most common intraocular tumor in childhood worldwide. The good prognosis in developed nations is related to early detection and advanced treatments.

Intravenous chemoreduction or intra-arterial chemotherapy for cavitary retinoblastoma: long-term results.

Objective: To assess the long-term results of chemotherapy for cavitary retinoblastoma.

Methods: Retrospective, nonrandomized, interventional case series of 26 cavitary retinoblastomas in 25 eyes of 24 patients. Retinoblastomas were treated with intravenous chemoreduction and/or intra-arterial chemotherapy.

Sector laser photocoagulation for the prevention of macular edema after plaque radiotherapy for uveal melanoma: a pilot study.

Objective: To investigate the role of sector laser photocoagulation for prevention of macular edema after plaque radiotherapy for uveal melanoma.

Methods: Noncomparative, pilot interventional case series. The main outcome measure was optical coherence tomography-evident macular edema.

Intravenous and intra-arterial chemotherapy for retinoblastoma: what have we learned?

Purpose Of Review: To review the recent literature on two methods of chemotherapy for retinoblastoma using intravenous versus intra-arterial route.

Recent Findings: In 1996, the era of intravenous chemotherapy (chemoreduction) for retinoblastoma was introduced with major centers providing published information on impressive tumor control, without the need for external beam radiotherapy or enucleation. Later reports heralded continued impressive long-term control, minimal systemic toxicities, likely prevention of pinealoblastoma (trilateral retinoblastoma), and reduction in numbers of germline mutation second cancers.

Combined hamartoma of the retina and retinal pigment epithelium in a child with branchial cleft cysts.

An otherwise healthy 15-month-old boy presented with benign branchial cleft cysts and combined hamartoma of the retina and retinal pigment epithelium. This association was previously only reported in a patient with branchio-oculo-facial syndrome. Although uncommon, this could represent multifocal sites of fetus craniofacial malformation.

Vitreous hemorrhage after plaque radiotherapy for uveal melanoma.

Purpose: The purpose of this article is to determine the incidence, etiology, management, and outcome of vitreous hemorrhage (VH) after plaque radiotherapy for uveal melanoma.

Methods: Retrospective review of medical records.

Results: Of 3,707 eyes treated with plaque radiotherapy for uveal melanoma, VH developed in 4.

Vitreous hemorrhage as the initial manifestation of idiopathic thrombocytopenic purpura.

Purpose: To report vitreous hemorrhage as the initial manifestation in idiopathic thrombocytopenic purpura, an uncommon presentation.

Methods: Case report.

Results: A 69-year-old white woman presented with diffuse vitreous hemorrhage as the initial manifestation of idiopathic thrombocytopenic purpura, 12 years after plaque radiotherapy for choroidal melanoma.

Fluorescein angiographic findings after intra-arterial chemotherapy for retinoblastoma.

Purpose: To evaluate fluorescein angiography (FA) findings after intra-arterial chemotherapy (IAC) for retinoblastoma.

Design: Retrospective case series.

Participants: Twenty-four eyes of 24 patients.

Plaque radiotherapy for residual or recurrent iris melanoma after surgical resection in 32 cases.

Purpose: To evaluate plaque radiotherapy for management of residual or recurrent iris melanoma after surgical resection.

Design: Retrospective, nonrandomized interventional case series.

Participants: We included 32 patients with residual or recurrent iris melanoma after surgical resection.

Effect of intraarterial chemotherapy on retinoblastoma-induced retinal detachment.

Purpose: To study the effect of intraarterial chemotherapy (IAC) on retinoblastoma-induced retinal detachment.

Methods: Retrospective, noncomparative, interventional case series including 15 patients, with intraarterial (ophthalmic artery) chemotherapy as the intervention. Resolution of retinal detachment was the main outcome measure.

Clinical survey of 3680 iris tumors based on patient age at presentation.

Objective: To report the spectrum of iris lesions based on patient age at presentation.

Design: Retrospective, nonrandomized, single-center case series.

Participants: We included 3680 iris tumors in 3451 patients.

Minimal exposure (one or two cycles) of intra-arterial chemotherapy in the management of retinoblastoma.

Purpose: To assess the efficacy of less than 3 cycles of intra-arterial chemotherapy (IAC) for retinoblastoma.

Design: Retrospective, nonrandomized, interventional case series.

Participants: Eight patients.

Oncocytic lesions (oncocytoma) of the ocular adnexa: report of 15 cases and review of literature.

Purpose: To describe the clinical, imaging, and pathology features of oncocytic lesions in the ocular adnexa.

Methods: Retrospective, noncomparative, interventional case series.

Results: Fifteen oncocytic neoplasms (n = 15 patients) were classified as oncocytoma in 14 (93%) and oncocytic hyperplasia in 1 (7%).