Publications by authors named "Bianca de Oliveira Horvath-Pereira"
Bone defects in animals can arise from various causes, including diseases, neoplasms, and most commonly, trauma. Comminuted fractures that exceed the critical size may heal poorly due to deficient or interrupted vascularization, resulting in an insufficient number of progenitor cells necessary for bone regeneration. In this context, 3D printing techniques using poly-L-lactic acid/graphene oxide (PLLA/GO) aim to address this issue by creating customized scaffolds combined with canine placenta hydrogel and mesenchymal stem cells for use in goat mandibles, compared to a control group using titanium plate fixation.
View Article and Find Full Text PDFType 1 diabetes mellitus (T1DM) is a chronic condition primarily managed with insulin replacement, leading to significant treatment costs. Complications include vasculopathy, cardiovascular diseases, nephropathy, neuropathy, and reticulopathy. Pancreatic islet transplantation is an option but its success does not depend solely on adequate vascularization.
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- The implantation of embryos into the uterus is a key process in mammalian reproduction, linked to the development of live births and placentation.
- This review highlights the different signals that recognize pregnancy and the various ways implantation occurs in eutherian mammals, emphasizing evolutionary diversity.
- While we have learned a lot about these processes, especially in rodents and bats, more research is needed on understudied species to better understand how implantation modes and pregnancy signaling have evolved.
Article Synopsis
- Printing customizable bone scaffolds is difficult due to the complex nature of bone tissue, but graphene oxide (GO) and poly-L-lactic acid (PLLA) show promise in bone regeneration.
- This study is the first to report the Fischer-Koch model for GO/PLLA in 3D printing, focusing on the reproducibility of scaffold features and their effects on cell viability.
- Results showed that the printed scaffolds are not cytotoxic and have favorable physicochemical properties, making them suitable for applications in bone tissue engineering and medical implants.
Placental scaffolds as a potential biological platform for embryonic stem cells differentiation into hepatic-like cells lineage: A pilot study.
Tissue Cell
October 2023
Article Synopsis
- The hepatic microenvironment is crucial for liver regeneration, with the extracellular matrix (ECM) providing structural support for cell growth and survival.
- The study explores the use of placental ECM as a scaffold for differentiating mouse embryonic stem cells into hepatocyte-like cells in a dynamic culture system.
- Preliminary results indicate successful cell adhesion and differentiation, with markers showing the presence of liver-like cells, suggesting that placental scaffolds could be a promising material for liver tissue reconstruction.
The application of decellularized scaffolds for artificial tissue reconstruction has been an approach with great therapeutic potential in regenerative medicine. Recently, biomimetic ovarian tissue reconstruction was proposed to reestablish ovarian endocrine functions. Despite many decellularization methods proposed, there is no established protocol for whole ovaries by detergent perfusion that is able to preserve tissue macro and microstructure with higher efficiency.
View Article and Find Full Text PDFTerm alpaca placenta glycosylation profile and its correlation with pregnancy maintenance and fetal survival.
Front Cell Dev Biol
June 2023
Alpaca is a South American camelid, particularly present in Peruvian highlands, where oxygen concentration and atmospheric pressure are very low. Due to this fact, gestational physiology has adapted to preserve the conceptus' and mother's health. In this context, several cellular and molecular features play an essential role during and at the end of gestation.
View Article and Find Full Text PDFBiomaterials for Testicular Bioengineering: How far have we come and where do we have to go?
Front Endocrinol (Lausanne)
April 2023
Traditional therapeutic interventions aim to restore male fertile potential or preserve sperm viability in severe cases, such as semen cryopreservation, testicular tissue, germ cell transplantation and testicular graft. However, these techniques demonstrate several methodological, clinical, and biological limitations, that impact in their results. In this scenario, reproductive medicine has sought biotechnological alternatives applied for infertility treatment, or to improve gamete preservation and thus increase reproductive rates and .
View Article and Find Full Text PDFCurrent Trends on Bioengineering Approaches for Ovarian Microenvironment Reconstruction.
Tissue Eng Part B Rev
June 2023
Article Synopsis
- * Current reproductive techniques like oocyte cryopreservation and ovarian tissue transplants have limitations, prompting the exploration of mimetic ovarian tissue reconstruction as a new solution for preserving germ cells and restoring ovarian function.
- * This review discusses advancements in ovarian tissue engineering, identifies limitations of existing preservation methods, and highlights key components and challenges in developing innovative techniques for restoring female fertility.
Shell fractures are one of the most traumatic and recurrent injuries observed in chelonians during clinical practice. The most common causes of fractures are falling, being run over by automobiles, being burned, and wild animal bites. Epoxy, acrylic resin, polyester, fiber-grass blanket, and screw fixation are among the current techniques used to treat fractures.
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