Publications by authors named "Bianca Portugal Tavares Moraes"
Background: Malaria, a tropical neglected disease, imposes a significant burden on global health, leading to the loss of thousands of lives annually. Its gold standard treatment is a combination therapy of lumefantrine (LUM) and artemether (ART). Nanotechnology holds significant potential for improving drug bioavailability and potency while reducing adverse effects.
View Article and Find Full Text PDFThe present study investigated the effects of murici and tapereba on improving hepatic and inflammatory biomarkers in high-fat-diet rats. Female Wistar rats were divided into five groups ( = 10/group): control (CON), high-fat diet (HF), murici drink + high-fat diet (Mu-HF), tapereba drink + high-fat diet (Tap-HF), and murici and tapereba blend drink + high-fat diet (MT-HF). Drinks were offered daily for 60 days, following which body and liver weights, hepatosomatic indexes, serum parameters, inflammatory profile, and antioxidant activity (DPPH and ORAC) were analyzed.
View Article and Find Full Text PDFFungal diseases are a significant cause of morbidity and mortality worldwide, primarily affecting immunocompromised patients. , , and are opportunistic fungi and may cause severe lung disease. They can develop mechanisms to evade the host immune system and colonize or cause lung disease.
View Article and Find Full Text PDFSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), identified for the first time in Wuhan, China, causes coronavirus disease 2019 (COVID-19), which moved from epidemic status to becoming a pandemic. Since its discovery in December 2019, there have been countless cases of mortality and morbidity due to this virus. Several compounds such as chloroquine, hydroxychloroquine, lopinavir-ritonavir, and remdesivir have been tested as potential therapies; however, no effective treatment is currently recommended by regulatory agencies.
View Article and Find Full Text PDFInflammatory, synaptic, motor, and behavioral alterations induced by gestational sepsis on the offspring at different stages of life.
J Neuroinflammation
February 2021
Article Synopsis
- - The study investigates how maternal sepsis affects cytokine levels and synaptic proteins in the brains of offspring mice, indicating potential lasting impacts on brain development and behavior.
- - Pregnant mice were exposed to sepsis through a bacterium, and the resulting offspring were assessed for motor skills, behavior, and cognitive abilities at different developmental stages.
- - Findings show that maternal sepsis leads to an increase in inflammatory cytokines and a decrease in important synaptic proteins, resulting in motor disabilities and behavioral issues, such as learning and memory problems in the young and adult mice.