Publications by authors named "Bianca P Gomez"
Background: Merkel cell carcinoma (MCC) is a relatively new addition to the expanding category of oncovirus-induced cancers. Although still comparably rare, the number of cases has risen dramatically in recent years. Further complicating this trend is that MCC is an extremely aggressive neoplasm with poor patient prognosis and limited treatment options for advanced disease.
View Article and Find Full Text PDFMerkel cell carcinoma (MCC) is a rare but devastating skin disease that is increasing in incidence within the United States. The poor prognosis of MCC patients and limited understanding of MCC pathogenesis warrants innovative treatments to control MCC. Several lines of evidence have pointed to Merkel cell polyomavirus (MCPyV) as the etiological agent of MCC.
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- - Human X-box binding protein-1 (XBP1) is a key factor in the unfolded protein response (UPR), helping cells handle stress from excess unfolded proteins, and its expression increases in antiestrogen-resistant breast cancer cells.
- - This study explores how XBP1 contributes to the growth of estrogen-positive breast cancer cells and their resistance to antiestrogen treatments like Tamoxifen and Faslodex, revealing that XBP1(S) enables growth independent of estrogen and reduces sensitivity to these drugs.
- - Findings suggest that XBP1(S) regulates important genes linked to cell survival and growth, indicating it could be a promising target for new treatment approaches in breast cancer.