Publications by authors named "Bianca Miguel Monti"
Antinociceptive effects of bupivacaine and its sulfobutylether-β-cyclodextrin inclusion complex in orofacial pain.
Juliana Souza de Freitas Domingues Silmara Martins Dias Dos Santos Julia das Neves Rodrigues Ferreira Bianca Miguel Monti Darciane Favero Baggio
Naunyn Schmiedebergs Arch Pharmacol
November 2022
Bupivacaine hydrochloride (BVC) represents an option to produce long-lasting analgesia, and complexation in cyclodextrins has shown improvements in biopharmaceutical properties. This study aimed to characterize and test the cytotoxicity and antinociceptive effects of BVC complexed in sulfobutylether-β-cyclodextrin (SBEβCD). The kinetics and stoichiometry of complexation and BVC-SBEβCD association constant were evaluated by phase solubility study and Job's plot.
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