Immune-Related Adverse Events Induced by Immune Checkpoint Inhibitors and CAR-T Cell Therapy: A Comprehensive Imaging-Based Review.

Immunotherapy has revolutionized oncology care, improving patient outcomes in several cancers. However, these therapies are also associated with typical immune-related adverse events due to the enhanced inflammatory and immune response. These toxicities can arise at any time during treatment but are more frequent within the first few months.

Interrelation between cardiac and brain small-vessel disease: a pilot quantitative PET and MRI study.

Background: Small-vessel disease (SVD) plays a crucial role in cardiac and brain ischemia, but little is known about potential interrelation between both. We retrospectively evaluated 370 patients, aiming at assessing the interrelation between cardiac and brain SVD by using quantitative Rb cardiac PET/CT and brain MRI.

Results: In our population of 370 patients, 176 had normal myocardial perfusion, 38 had pure cardiac SVD and 156 had obstructive coronary artery disease.

Isolated superior striate vein thrombosis in adults.

Background: Isolated cerebral deep medullary vein thrombosis has been described in the setting of hemorrhagic periventricular white matter lesions in preterm and full-term neonates, but to the best of our knowledge, has never been reported in adults. We present two cases of isolated thrombosis of the superior striate vein occurring in adults that could be analogous to deep medullary vein thrombosis in that they involve deep cerebral veins only without thrombosis of the subependymal or internal cerebral veins.

Case Description: Two women aged 20 and 39, presented with transient neurological deficits and headache.