Metformin does not reduce inflammation in diabetics with abdominal aortic aneurysm or at high risk of abdominal aortic aneurysm formation.

Introduction: The protective effect of diabetes mellitus on abdominal aortic aneurysm formation and growth has been repeatedly observed in population studies but continues to be poorly understood. However, recent investigations have suggested that metformin, a staple antihyperglycemic medication, may be independently protective against abdominal aortic aneurysm formation and growth. Therefore, we describe the effect of metformin in abdominal aortic aneurysm and at-risk patients on markers of inflammation, the driver of early abdominal aortic aneurysm formation and growth.

Surgical margins and primary site resection in achieving local control in oral cancer resections.

Objectives/hypothesis: Evaluate effectiveness of resection of oral cavity cancer with a standardized approach for margin evaluation. Primary end points were local control and survival.

Study Design: Retrospective, nonrandomized, single institution.

Anatomic evaluation of endoscopic transnasal transorbital approach to the lateral orbital apex.

Background: This anatomic study investigates the feasibility of an endoscopic transnasal transorbital approach to the lateral orbital apex.

Methods: Five cadavers with no prior history of sinus surgery were studied bilaterally. Standard techniques and instrumentation for functional endoscopic sinus surgery were used to perform dissections and delineate anatomy of sinuses and orbits.