Purpose: To evaluate survival and ocular outcome in recurrent uveal melanoma treated with proton beam therapy as salvage therapy.
Design: Retrospective, interventional case series.
Methods: We evaluated 48 patients with local recurrence of uveal melanoma after primary treatment with brachytherapy, transpupillary thermotherapy, proton beam therapy, laser photocoagulation, CyberKnife radiation, or photodynamic therapy.
Purpose: To compare interferon (IFN) beta with methotrexate (MTX) in the treatment of intermediate uveitis with macular edema.
Design: Monocentric, prospective, randomized, controlled clinical trial.
Setting: Specialized uveitis center at the University of Heidelberg.
Objective: The aim of this study was to assess the efficacy of adalimumab in patients with active non-infectious uveitis in three different centres.
Methods: In a retrospective study we identified patients from our databases who were treated with adalimumab. The composite outcome measure for efficacy included reduction of macular oedema by optic coherence tomography, visual acuity, anterior chamber cells, reduction of frequency of flares and reduction of prednisone dose during the treatment.
Purpose: Chemokine receptors and their ligands are involved in a number of cell processes, including normal cell trafficking as well as metastasis in cancer. During metastasis, they are thought to play a role in determining cancer cell distribution and target organs. The aim of this study was to examine the expression of the chemokine receptors CXCR4, CCR7 and CCR10 as well as their respective chemokine ligands (CXCL12, CCL19, CCL27) in human uveal melanomas.
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