Behaviorally specific versus non-specific suppression of accumbens shell-mediated feeding by ipsilateral versus bilateral inhibition of the lateral hypothalamus.

The nucleus accumbens shell (AcbSh) and lateral hypothalamus (LH) are linked in the control of food intake. Pharmacological inhibition of the LH may block AcbSh-elicited feeding, but the behavioral phenotype associated with this feeding suppression is unknown. To examine this phenotype, adult male Sprague-Dawley rats were implanted with three cannulas - one unilaterally in the AcbSh and two bilaterally in the LH - to allow for central drug injections.