Publications by authors named "Bianca Cody"
Carcinogenesis
November 2012
Article Synopsis
- Transforming growth factor-beta (TGF-β) and Nodal, both members of the TGF-β superfamily, have varying effects on prostate cancer cells, with TGF-β generally acting as a tumor suppressor and Nodal contributing to tumor promotion in certain contexts.
- Nodal and TGF-β inhibited cell proliferation in some prostate cancer cell lines but induced increased migration in others; they also exhibited different effects on the phosphorylation of Smad proteins, with TGF-β primarily affecting Smad3 and Nodal affecting only Smad2.
- The protein Ski, which represses Smad signaling, was found at higher levels in prostate cancer tissues and cells; TGF-β reduces
