A cytochrome repressed by a MarR family regulator confers resistance to metals, nitric oxide, sulfide, and cyanide in .

Unlabelled: is a ubiquitous environmental pathogen. Despite its remarkable adaptability, little is known about the mechanisms of stress resistance in this bacterium. Here, in a screen for iron-susceptible transposon mutants, we identified a cytochrome that protects against multiple stresses.

Static Versus Expandable Cages in Minimally Invasive Lateral Lumbar Interbody Fusion: A Systematic Review and Meta-Analysis.

Study Design: A meta-analysis approach to a systematic review.

Objective: Perform a systematic review to identify all reports directly comparing outcomes of lateral lumbar interbody fusion (LLIF) using static versus expandable interbody cages. Specifically focusing on periprocedural complications, intraoperative morbidity, and fusion outcomes.

A cytochrome repressed by a MarR family regulator confers resistance to metals, nitric oxide, sulfide, and cyanide in .

Unlabelled: is a ubiquitous environmental pathogen. Despite its remarkable adaptability, little is known about the mechanisms of stress resistance in this bacterium. Here, in a screen for iron-susceptible transposon mutants, we identified a cytochrome that protects against multiple stresses.

A quorum-sensing regulatory cascade for siderophore-mediated iron homeostasis in .

Iron is a transition metal used as a cofactor in many biochemical reactions. In bacteria, iron homeostasis involves Fur-mediated de-repression of iron uptake systems, such as the iron-chelating compounds siderophores. In this work, we identified and characterized novel regulatory systems that control siderophores in the environmental opportunistic pathogen .

The Regulatory Protein ChuP Connects Heme and Siderophore-Mediated Iron Acquisition Systems Required for Virulence.

is an environmental Gram-negative beta-proteobacterium that causes systemic infections in humans. uses siderophore-based iron acquisition systems to overcome the host-imposed iron limitation, but its capacity to use other iron sources is unknown. In this work, we characterized ChuPRSTUV as a heme utilization system employed by to explore an important iron reservoir in mammalian hosts, free heme and hemoproteins.

Ferric Uptake Regulator Fur Coordinates Siderophore Production and Defense against Iron Toxicity and Oxidative Stress and Contributes to Virulence in Chromobacterium violaceum.

Iron is a highly reactive metal that participates in several processes in prokaryotic and eukaryotic cells. Hosts and pathogens compete for iron in the context of infection. , an environmental Gram-negative bacterial pathogen, relies on siderophores to overcome iron limitation in the host.

Production and Uptake of Distinct Endogenous Catecholate-Type Siderophores Are Required for Iron Acquisition and Virulence in Chromobacterium violaceum.

Bacteria use siderophores to scavenge iron from environmental or host sources. The iron acquisition systems of , a ubiquitous environmental bacterium that can cause infections in humans, are still unknown. In this work, we demonstrated that produces putative distinct endogenous siderophores, here named chromobactin and viobactin, and showed that they are each required for iron uptake and virulence.

Increased serum gastrin in patients with different clinical forms of Chagas disease coinfected with Helicobacter pylori.

Trypanosoma cruzi and Helicobacter pylori (HP) are pathogens that cause chronic diseases and have been associated with hypergastrinemia. The aim of this study was to evaluate the fasting gastrin levels in patients with different clinical forms of Chagas disease (CD), coinfected or not by HP. The enrolled individuals were outpatients attending at the university hospital.

EmrR-Dependent Upregulation of the Efflux Pump EmrCAB Contributes to Antibiotic Resistance in .

is an environmental Gram-negative bacterium that causes infections in humans. Treatment of infections is difficult and little is known about the mechanisms of antibiotic resistance in this bacterium. In this work, we identified mutations in the MarR family transcription factor EmrR and in the protein GyrA as key determinants of quinolone resistance in , and we defined EmrR as a repressor of the MFS-type efflux pump EmrCAB.

Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode.

Cell surface glycans form a critical interface with the biological milieu, informing diverse processes from the inflammatory cascade to cellular migration. Assembly of discrete carbohydrate structures requires the coordinated activity of a repertoire of proteins, including glycosyltransferases and glycosidases. Little is known about the regulatory networks controlling this complex biosynthetic process.

Identification of a conserved glycan signature for microvesicles.

Microvesicles (exosomes) are important mediators of intercellular communication, playing a role in immune regulation, cancer progression, and the spread of infectious agents. The biological functions of these small vesicles are dependent on their composition, which is regulated by mechanisms that are not well understood. Although numerous proteomic studies of these particles exist, little is known about their glycosylation.

Evaluation of sleep habits in children with epilepsy.

Sleep disturbances are a common complaint among patients with epilepsy. Studies assessing the relationship between sleep and epilepsy during childhood are scarce. The purpose of this study was to evaluate sleep habits in children with epilepsy.

[Use of psychoactive and antiepileptic drugs: guidelines for pediatricians].

Objective: To review the guidelines for the use of psychoactive and antiepileptic drugs in childhood and adolescence.

Sources Of Data: Literature review.

Summary Of The Findings: The clinical indications, dosage and side effects of psychoactive and antiepileptic drugs are presented.

[Effects of early malnutrition and nutritional rehabilitation in rats].

OBJECTIVE: To verify the effects of malnutrition and nutritional rehabilitation regarding seizure threshold, body weight and brain weight in rats. METHODS: Pregnant Wistar rats and their pups were used. Part of the rat pups were submitted to a malnutrition protocol and the rest served as nourished controls.

[Progressive bulbar palsy (Fazio-Londe disease): case report].

Progressive bulbar palsy, also called Fazio -Londe disease, is characterized by progressive impairment of cranial nerves in children. It was first reported by Fazio in 1892 and until now only 30 cases have been published in the literature. Both sexes can be affected and clinical course can be divided on early (< 6 years age, predominance of respiratory symptoms) and late course (6-20 years of age, predominance of motor symptoms on superior limbs).