Synthesis, crystal structure and Hirshfeld analysis of -bis-{(2)--phenyl-2-[(2)-3-phenyl-2-propen-1-yl-idene]hydrazinecarbo-thio-amidato-κ,}palladium(II).

The reaction of (2)--phenyl-2-[(2)-3-phenyl-2-propen-1-yl-idene]hydra-zine-carbo-thio-amide (common name: cinnamaldehyde-4-phenyl-thio-semi-carbazone) deprotonated with NaOH in ethanol with an ethano-lic suspension of Pd chloride in a 2:1 molar ratio yielded the title compound, [Pd(CHNS)]. The anionic ligands act as metal chelators, κ -donors, forming five-membered rings with a -configuration. The Pd ion is fourfold coordinated in a slightly distorted square-planar geometry.

Pre-clinical evidence of safety and protective effect of isatin and oxime derivatives against malathion-induced toxicity.

The inhibition of acetylcholinesterase (AChE) is a common outcome caused by organophosphorus (OPs) intoxication. Although inconsistent, the standard treatment consists of a muscarinic receptor antagonist (atropine) and AChE-reactivating molecules such as oximes. This study proposes to test unpublished compounds which contain the moieties of isatin and/or oxime have protective effects against the toxicity induced by malathion in two animal models: Artemia salina and Rattus norvegicus (Wistar rats).

(3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one attenuates hyperglycemia, increased hepatic glycogen content and hepatic damage induced by malathion acute exposure in rats.

Background: Organophosphorus pesticides (OP's) are heavily constituted in agriculture, gardens, home and veterinary and although it is useful, there are concerns about the environment, safety and health of human and animals. In this study, we investigated the effects of a new oxime, (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one (OXIME) against the alterations induced by malathion, an OP insecticide, acute exposure on markers of hepatic damage, glucose homeostasis, oxidative stress in rats cholinesterase (ChE) activity in rats.

Methods: Adult male Wistar rats were divided into four groups: Control; Malathion; OXIME; and Malathion+OXIME.

Crystal structure and Hirshfeld analysis of -bis-(5-fluoro-indoline-2,3-dione 3-oximato-κ,)--bis-(pyridine-κ)copper(II).

The reaction in methanol of Cu acetate monohydrate with 5-fluoro-isatin 3-oxime deprotonated with KOH in a 1:2 molar ratio and recrystallization from pyridine yielded the title compound, [Cu(CHFNO)(CHN)]. In the centrosymmetric complex, the anionic form of the isatin oxime acts as a κ, donor, building five-membered metallarings. The Cu cation is sixfold coordinated in a slightly distorted octa-hedral environment by two , equatorial, anionic isatin derivatives and two pyridine ligands in axial positions.

Crystal structure, Hirshfeld analysis and mol-ecular docking with the vascular endothelial growth factor receptor-2 of (3)-5-fluoro-3-(hy-droxy-imino)-indolin-2-one.

The reaction between 5-fluoro-isatin and hydroxyl-amine hydro-chloride in acidic ethanol yields the title compound, CHFNO, whose mol-ecular structure matches the asymmetric unit and is nearly planar with an r.m.s.

A one-dimensional coordination polymer constructed from isatine-3-oximate and sodium.

The reaction of hydroxyl-amine hydro-chloride with isatin in ethanol, catalysed with HCl and neutralized with Na(2)CO(3), yielded the one-dimensional coordination polymer, catena-poly[[[aqua-sodium]-di-μ-aqua-[aqua-sodium]-bis-(μ-2-oxoindoline-2,3-dione 3-oximato)] tetra-kis-(oxoindoline-2,3-dione 3-oxime)], {[Na(C(8)H(5)N(2)O(2))(H(2)O)(2)]·2C(8)H(6)N(2)O(2)}(n). The Na(I) atom has a six-coordinate distorted-octa-hedral environment. Isatine-3-oximate O atoms and water mol-ecules bridge adjacent Na atoms, forming a one-dimensional polymeric structure parallel to [100].