Publications by authors named "Bianca Altenburg"
Article Synopsis
- * The study explored the drug's effects on telomere length and cellular growth using induced pluripotent stem cells (iPSCs), revealing that while imetelstat reduced growth in the patient's original cells, it did not affect the growth of iPSC-derived cells.
- * The findings suggested that imetelstat targets JAK/STAT signaling more effectively in CALR-mutated cells compared to JAK2-mutated cells, indicating that patients with CALR mutations may benefit significantly from imetelstat treatment. *
Structural analogues of PFI-1 varying at the sulfur core were prepared, and their activities as BET inhibitors in myeloid cell lines and primary cells from patients with acute myeloid leukemia were studied. Docking calculations followed by molecular dynamics simulations revealed the binding mode of the newly prepared inhibitors, suggesting explanations for the observed high enantiospecificity of the inhibitory activity.
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