Tumor microenvironment-responsive multinucleated nanocomplexes loaded with carbon dots for combined photothermal/chemodynamic therapy of breast cancer.

Low cure rate and high death rate of cancers have seriously threatened human health. The combining multiple therapies is a promising strategy for cancer treatment. In this study, we construct a novel multinucleated nanocomplex loaded with carbon dots (CDs-SA@TAMn) that responds to tumor microenvironment for combined photothermal/chemodynamic cancer therapy.

A Theoretical Study on Crossings Among Electronically Excited States and Laser Cooling of Group VIA (S, Se, and Te) Hydrides.

Various electronically excited states and the feasibility of direct laser cooling of SH, SeH, and TeH are investigated using the highly accurate ab initio and dynamical methods. For the detailed calculations of the seven low-lying Λ-S states of SH, we utilized the internally contracted multireference configuration interaction approach, considering the spin-orbit coupling (SOC) effects. Our calculated spectroscopic constants are in very good agreement with the available experimental results.

Bupivacaine multivesicular liposomes/meloxicam nanocrystals in a thermosensitive gel adapted to the "microenvironment" for long-term analgesia.

Current analgesics on the market exhibit a short duration of action and induce the production of inflammatory factors in tissues damaged by surgical procedures. Inflammatory factor production can create acidic environments, limiting drug delivery. In this study, we developed a novel injectable formulation comprising bupivacaine multivesicular liposomes of high osmotic pressure (H-MVL) and meloxicam nanocrystals (MLX) in a thermosensitive gel (H-MVL/MLX@GEL) adapted to the microenvironment for long-term postoperative analgesia.

How to monitor and discriminate the causes of lower limb swelling during home-based rehabilitation after total knee arthroplasty? A delphi study.

Purpose: Swelling in the lower limbs after total knee arthroplasty (TKA) affects surgical outcomes. Prolonged swelling requires monitoring and remote management during home-based rehabilitation. Causes of swelling vary but, so far, no indicators are available to monitor and identify causes of lower limb swelling, making it difficult to implement targeted interventions.

Approaching the standard quantum limit of a Rydberg-atom microwave electrometer.

The development of a microwave electrometer with inherent uncertainty approaching its ultimate limit carries both fundamental and technological significance. However, because of the thermal motion of atoms, the state-of-art Rydberg electrometer falls considerably short of the standard quantum limit by about three orders of magnitude. Here, we use an optically thin medium with approximately 5.

Changes in complement C3a in the immunotherapy of advanced clear cell renal cell carcinoma.

Background: Immunotherapy is an emerging treatment modality for clear cell renal cell carcinoma (CCRCC). As a molecule involved in the prognosis of CCRCC, the effect of complement C3a expression levels on immunotherapy is unclear. This study aims to investigate the correlation between C3a and clinicopathological features in early CCRCC, as well as the alterations in complement C3a during immunotherapy for advanced CCRCC and its influence on therapeutic outcomes.

Fano Resonance-Associated Plasmonic Circular Dichroism in a Multiple-Dipole Interaction Born-Kuhn Model.

Plasmon chirality has garnered significant interest in sensing application due to its strong electromagnetic field localization and highly tunable optical properties. Understanding the effects of mode coupling in chiral structures on chiral optical activity is particularly important for advancing this field. In this work, we numerically investigate the circular dichroism (CD) of elliptical nanodisk dimers arranged in an up-and-down configuration with a specific rotation angle.

Analysis and Validation of a Diagnostic Nomogram for Predicting the Risk of Acute Respiratory Failure for Non-HIV Related Pneumocystis Jirovecii Pneumonia Patients.

Objective: Pneumocystis Pneumonia (PCP), primarily affecting individuals with weakened immune systems, is a severe respiratory infection caused by pneumocystis jirovecii and can lead to acute respiratory failure (ARF). In this article, we explore the risk factors of ARF and propose a prognostic model of ARF for PCP patients.

Methods: In this multi-center, retrospective study in 6 secondary or tertiary academic hospitals in China, 120 PCP patients were screened from the Dryad database for the development of a predictive model.

In Situ Self-Assembled 200 nm-Depth Highly Active Layer Non-Precious Metals Catalyst for Industrial Water Electrolysis.

Nickel-based electrocatalysts are promising for industrial water electrolysis, but the dense hydroxyl oxide layer formed during the oxygen evolution reaction (OER) limits active sites accessibility and presents challenges in balancing structural stability with effective charge transfer. Based on this, an efficient in situ leaching strategy is proposed to construct grain boundary-rich catalyst structure with high charge transfer ability and a deep catalytic active layer reached >200-nm. Under OER conditions, stable sub-nano NiAl particles are embedded in Ni(Fe)OOH, originating from leaching out the unstable NiAl phase of the initial NiAl/NiAl alloy doped with Fe.

A Facile Label-Free Colorimetric Assay for DNase I Activity Based on the Peroxidase-Like Activity of Functional Nucleic Acids.

DNase I plays a crucial role in fundamental biological processes, including gene expression, DNA repair, and apoptosis. Therefore, it is important to develop a simple and efficient method to detect DNase I activity. In this work, a colorimetric assay based on functional nucleic acid for sensitive DNase I detection was reported.

Development and Testing of a Multi-Component Intervention to Improve Medication Literacy in Glaucoma Patients.

Objective: To develop a medication literacy intervention program for glaucoma and test its effects on medication literacy, medication self-efficacy and medication adherence.

Methods: The intervention was constructed according to the Information-Motivation-Behavioral skills Model and the Health Belief Model. Preliminary protocols were revised through expert group meetings and pre-experiments to form a formal intervention plan.

Multi-task magnetic resonance imaging reconstruction using meta-learning.

Using single-task deep learning methods to reconstruct Magnetic Resonance Imaging (MRI) data acquired with different imaging sequences is inherently challenging. The trained deep learning model typically lacks generalizability, and the dissimilarity among image datasets with different types of contrast leads to suboptimal learning performance. This paper proposes a meta-learning approach to efficiently learn image features from multiple MRI datasets.

Adolescent sleep and its disruption in depression and anxiety.

Adolescence is a pivotal stage during development when one's personality, emotion, and behavioral traits are shaped to a great extent, and the underlying neural circuits undergo substantial developmental organizations. Dramatic and dynamic changes occur in sleep architecture throughout the postnatal developmental course. Insufficient sleep and disruption of sleep/wake coherence are prevalent among the adolescents worldwide, and even so in young patients with neuropsychiatric conditions.

Extracorporeal membrane oxygenation in obstetrical patients: a meta-analysis.

Critically acute and ill and Obstetrical patients constitute a unique clinical population with a high mortality rate. Extracorporeal membrane oxygenation (ECMO) is gradually being used in obstetrical acute and critically ill patients and has shown great advantages. PubMed, Embase, Web of Science, Chinese CNKI Database, and Cochrane Library databases were systematically searched from the earliest available date to March 15, 2024, to obtain relevant studies on extracorporeal membrane oxygenation in obstetric patients.

Circ_0008035 Promotes Gastric Cancer Development via the miR-429/SMAD2 Cascade.

The vital roles of circular RNAs (circRNAs) in human tumorigenesis have attracted more attention. Circ_0008035 is one of the most up-regulated circRNAs in gastric cancer (GC). Herein, we explored the associated mechanism of circ_0008035 in GC.

Point Clouds Matching Based on Discrete Optimal Transport.

Matching is an important prerequisite for point clouds registration, which is to establish a reliable correspondence between two point clouds. This paper aims to improve recent theoretical and algorithmic results on discrete optimal transport (DOT), since it lacks robustness for the point clouds matching problems with large-scale affine or even nonlinear transformation. We first consider the importance of the used prior probability for accurate matching and give some theoretical analysis.

Unveiling the Dynamic Evolution of Catalytic Sites in N-Doped Leaf-like Carbon Frames Embedded with Co Particles for Rechargeable Zn-Air Batteries.

The advancement of cost-effective, high-performance catalysts for both electrochemical oxygen reduction reactions (ORRs) and oxygen evolution reactions (OERs) is crucial for the widespread implementation of metal-air batteries. In this research, we fabricated leaf-like N-doped carbon frames embedded with Co nanoparticles by pyrolyzing a ZIF-L/carbon nanofiber (ZIF-L/CNF) composite. Consequently, the optimized ZIF-L/CNF-700 catalyst exhibit exceptional catalytic activities in both ORRs and OERs, comparable to the benchmark 20 % Pt/C and RuO.

Machine learning-based prediction of early neurological deterioration after intravenous thrombolysis for stroke: insights from a large multicenter study.

Background: This investigation seeks to ascertain the efficacy of various machine learning models in forecasting early neurological deterioration (END) following thrombolysis in patients with acute ischemic stroke (AIS).

Methods: Employing data from the Shenyang Stroke Emergency Map database, this multicenter study compiled information on 7,570 AIS patients from 29 comprehensive hospitals who received thrombolytic therapy between January 2019 and December 2021. An independent testing cohort was constituted from 2,046 patients at the First People's Hospital of Shenyang.

Encapsulated TADF macrocycles for high-efficiency solution-processed and flexible organic light-emitting diodes.

Macrocyclic thermally activated delayed fluorescence (TADF) emitters have been demonstrated to realize high efficiency OLEDs, but the design concept was still confined to rigid π-conjugated structures. In this work, two macrocyclic TADF emitters, Cy-BNFu and CyEn-BNFu, with a flexible alkyl chain as a linker and bulky aromatic hydrocarbon wrapping units were designed and synthesized. The detailed photophysical analysis demonstrates that the flexible linker significantly enhances the solution-processibility and flexibility of the parent TADF core without sacrificing the radiative transition and high PLQY.