HDAC inhibitor enhances ferroptosis susceptibility of AML cells by stimulating iron metabolism.

Acute Myeloid Leukemia (AML) are challenging blood cancers with limited long-term survival rates, necessitating novel therapeutic strategies. This study explored the role of Histone deacetylase (HDAC) inhibitors in enhancing ferroptosis in AML cells by modulating iron metabolism. We demonstrated that HDAC inhibitors (Entinostat and Vorinostat) sensitize AML cells to ferroptosis both in vitro and in vivo.

Multimaterial cryogenic printing of three-dimensional soft hydrogel machines.

Hydrogel-based soft machines are promising in diverse applications, such as biomedical electronics and soft robotics. However, current fabrication techniques generally struggle to construct multimaterial three-dimensional hydrogel architectures for soft machines and robots, owing to the inherent hydrogel softness from the low-density polymer network nature. Herein, we present a multimaterial cryogenic printing (MCP) technique that can fabricate sophisticated soft hydrogel machines with accurate yet complex architectures and robust multimaterial interfaces.

Analysis of carbon reduction potential from typical municipal solid waste incineration plants under MSW classification.

The disposal of municipal solid waste (MSW) is a significant source of greenhouse gas (GHG) emissions. As incineration becomes the primary method of MSW disposal in China, MSW incineration (MSWI) plants are expected to play a crucial role in mitigating GHG emissions in the waste sector. This study estimated the quarterly GHG emissions from two representative MSWI plants in Qingdao using a life-cycle assessment (LCA) approach.

Evidence of sewage discharge on the coalescence mechanism of aquatic microbial communities during high amplitude hydrological periods.

Microbial community coalescence is a ubiquitous ecological process in various ecosystems. However, limited research has addressed the effects of the coalescence on microbial ecological processes and network structure, particularly in the context of sewage discharge during high amplitude hydrological periods. Employing 16S rRNA sequencing and species source tracking analysis, we investigated the coalescence pattern of bacterioplankton in the Chishui river and sewage across various hydrological periods.

Differences in soil Cd immobilization and blockage of rice Cd uptake by biochar derived from crop residue and bone - A 2-year field experiment.

Biochar is widely recognized as an effective amendment for soils contaminated with cadmium (Cd). However, the properties and elemental compositions of biochar derived from different feedstocks may significantly impact the transfer of Cd in the soil-rice system. This study conducted a two-year field trial in Cd-contaminated paddy soil.

A Nomogram for Predicting Recurrence in Stage I Non-Small Cell Lung Cancer.

Background: Early-stage non-small cell lung cancer (NSCLC) is being diagnosed increasingly, and in 30% of diagnosed patients, recurrence will develop within 5 years. Thus, it is urgent to identify recurrence-related markers to optimize the management of patient-tailored therapeutics.

Methods: The eligible datasets were downloaded from TCGA and GEO.

Dynamic covalent bonds enabled recyclable chitosan oligosaccharide-based wood adhesive with high adhesion and anti-mildew performances.

Biomass wood adhesives have emerged as a promising alternative to traditional synthetic resins due to their ability to address issues related to formaldehyde pollution and reliance on petrochemical resources. However, these adhesives are generally not recyclable and require high curing temperatures. Herein, a novel eco-friendly, strong, and recyclable chitosan oligosaccharide (CS)-based wood adhesive named CS-PB was developed using CS, lignin-derived 3,4-dihydroxybenzaldehyde, and 1,4-phenylenediboronic acid.

Type II cryoglobulinemia in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma and Sjögren's disease.

Type II cryoglobulinemia is a rare disorder characterized by abnormal immunoglobulins (Igs) precipitating in the blood at low temperatures and redissolving upon warming. Sjogren's disease (SjD) is an autoimmune disorder involving secretory gland malfunction that leads to persistent dryness of the mouth and eyes. Here, we report the case of a 61-year-old woman with a 7-year history of SjD who was diagnosed with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL).

CDKN1A as a target of senescence in heart failure: insights from a multiomics study.

Background: Cardiomyocyte senescence plays a crucial role as a pathological mechanism in heart failure (HF). However, the exact triggering factors and underlying causes of HF onset and progression are still not fully understood.

Objectives: By integrating multi-omics data, this study aimed to determine the genetic associations between cardiomyocyte and HF using cell senescence-related genes (SRGs).

Insights into bioaerosol contamination in the process of mineralized refuse mining: Microbial aerosolization behavior and potential pathogenicity.

The landfill mining process is a main source of anthropogenic bioaerosol release, posing potential risks to the health of occupationally exposed personnel and nearby residents. In this study, microbial aerosolization behavior and potential pathogenicity during the landfill mining process were systematically investigated. The highest concentration of bacterial aerosols was measured in the refuse mining area, with a value of 5968 ± 1608 CFU/m, while the highest concentration of fungal aerosols was 1196 ± 370 CFU/m in the refuse screening area.

Iron-modified biochars and their aging reduce soil cadmium mobility and inhibit rice cadmium uptake by promoting soil iron redox cycling.

Iron (Fe) modified biochar has been widely used for cadmium (Cd) contaminated soil remediation. However, the accompanying anions introduced during the modification process potentially affect the behavior of Cd in soil. In this study, we investigated the distinct Cd immobilization mechanisms by Fe(SO) modified biochar (FSBC) and Fe(NO) modified biochar (FNBC) in a two-year pot experiment.

Harnessing the benefits of physical exercise-induced melatonin: a potential promising approach to combat Alzheimer's disease by targeting beta-amyloid (Aβ).

Alzheimer's disease (AD) is a chronic neurogenerative disease that impairs cognition, learning, behavior, and memory. The aberrant accumulation of extracellular amyloid-β (Aβ) plaques is a characteristic of AD. It has been demonstrated that melatonin exerts a significant role in AD prevention and treatment via its antioxidant effects, reducing neuroinflammation, and Aβ.

The impact of immunity on the risk of coronary artery disease: insights from a multiomics study.

Background: Immune inflammation is intricately associated with coronary artery disease (CAD) progression, necessitating the pursuit of more efficacious therapeutic strategies. This study aimed to uncover potential therapeutic targets for CAD and myocardial infarction (MI) by elucidating the causal connection between regulatory immune-related genes (RIRGs) and these disorders.

Methodology: We performed summary data-based Mendelian randomization analysis to assess the therapeutic targets linked to expression quantitative trait loci and methylation quantitative trait loci of RIRGs in relation to CAD and MI.

Diversity matters: Cross-head mutual mean-teaching for semi-supervised medical image segmentation.

Semi-supervised medical image segmentation (SSMIS) has witnessed substantial advancements by leveraging limited labeled data and abundant unlabeled data. Nevertheless, existing state-of-the-art (SOTA) methods encounter challenges in accurately predicting labels for the unlabeled data, giving rise to disruptive noise during training and susceptibility to erroneous information overfitting. Moreover, applying perturbations to inaccurate predictions further impedes consistent learning.

Solidification/stabilization pre-treatment coupled with landfill disposal of heavy metals in MSWI fly ash in China: A systematic review.

The growth in municipal solid waste incineration (MSWI) has resulted in a substantial rise in the production of fly ash in China. It is anticipated that during the "14th Five-Year Plan", the accumulated amount of fly ash stocked and disposed of at landfills will surpass 100 million tons. With the development of the economy and the implementation of garbage classification relevant policies, the pollution characteristics of heavy metal change in spatiotemporal distribution.

Magnetic Chitosan/ZrO Composites for Vanadium(V) Adsorption while Concurrently being Transformed to a Dual Functional Catalyst.

Spent adsorbents for recycling as catalysts have drawn considerable attention due to their environmentally benign chemistry properties. However, traditional thermocatalytic strategies limit their applications. Here, we developed an enhanced photocatalytic strategy to expand the range of their applications.

Arabidopsis WRKY1 promotes monocarpic senescence by integrative regulation of flowering, leaf senescence, and nitrogen remobilization.

Monocarpic senescence, characterized by whole-plant senescence following a single flowering phase, is widespread in seed plants, particularly in crops, determining seed harvest time and quality. However, how external and internal signals are systemically integrated into monocarpic senescence remains largely unknown. Here, we report that the Arabidopsis thaliana transcription factor WRKY1 plays essential roles in multiple key steps of monocarpic senescence.

Combining Functional Units to Design Organic Materials with Dynamic Room-Temperature Phosphorescence under Continuous Ultraviolet Irradiation.

Developing materials with dynamic room-temperature phosphorescence (RTP) properties is crucial for expanding the applications of organic light-emitting materials. In this study, we designed and synthesized two novel RTP molecules by combining functional units, incorporating the folded unit thianthrene into the classic luminescent cores thioxanthone or anthraquinone to construct TASO and TA2O. In this combination, the TA unit contributes to the enhancement of spin-orbit coupling (SOC), while the luminescent core governs the triplet energy level.

Risk factors influencing postoperative outcome of arthroscopic rotator cuff repair and construction of a nomogram prediction model.

Objective: To investigate the risk factors influencing the postoperative outcome of arthroscopic rotator cuff repair (ARCR) and develop a nomogram prediction model.

Methods: A retrospective study was conducted on 302 patients who underwent ARCR from January 2019 to August 2023. Patients were categorized into two groups: a control group with 150 patients showing good recovery and an observation group with 152 patients exhibiting poor recovery.

Developing fatigue-resistant ferroelectrics using interlayer sliding switching.

Ferroelectric materials have switchable electrical polarization that is appealing for high-density nonvolatile memories. However, inevitable fatigue hinders practical applications of these materials. Fatigue-free ferroelectric switching could dramatically improve the endurance of such devices.

Compensation of small data with large filters for accurate liver vessel segmentation from contrast-enhanced CT images.

Background: Segmenting liver vessels from contrast-enhanced computed tomography images is essential for diagnosing liver diseases, planning surgeries and delivering radiotherapy. Nevertheless, identifying vessels is a challenging task due to the tiny cross-sectional areas occupied by vessels, which has posed great challenges for vessel segmentation, such as limited features to be learned and difficult to construct high-quality as well as large-volume data.

Methods: We present an approach that only requires a few labeled vessels but delivers significantly improved results.

Characterization of a new greenbug resistance gene Gb9 in a synthetic hexaploid wheat.

Greenbug [Schizaphis graminum (Rondani)] is a serious insect pest that not only damages cereal crops, but also transmits several destructive viruses. The emergence of new greenbug biotypes in the field makes it urgent to identify novel greenbug resistance genes in wheat. CWI 76364 (PI 703397), a synthetic hexaploid wheat (SHW) line, exhibits greenbug resistance.