Publications by authors named "Bi-Yue Zhou"
PLoS Negl Trop Dis
August 2024
Article Synopsis
- Schistosomiasis, affecting over 250 million globally, relies heavily on praziquantel (PZQ) for treatment, but this method is unsustainable, leading to a push for new drug candidates.
- A study identified curcumin as the most effective inhibitor against Schistosoma japonicum, with notable impacts on both juvenile and adult parasites, while two other inhibitors had limited effects.
- Both curcumin and a PZQ derivative (DW-3-15) significantly reduced the expression of a key protein (SjHAT), suggesting that SjHAT could be a promising target for innovative antischistosomal treatments.
