Publications by authors named "Bi-Xiao Xiang"
Background: Polymyxins have re-emerged as a last-resort therapeutic option for infections caused by carbapenem-resistant gram-negative bacteria. Nephrotoxicity induced by polymyxins is a significant limitation of its use in the clinic. Polymyxin B and colistin sulfate are two widely used active formulations of polymyxins.
View Article and Find Full Text PDFObjectives: Polymyxin-induced nephrotoxicity (PIN) is a major safety concern and challenge in clinical practice, which limits the clinical use of polymyxins. This study aims to investigate the risk factors and to develop a scoring tool for the early prediction of PIN.
Methods: Data on critically ill patients who received intravenous polymyxin B or colistin sulfate for over 24 h were collected.
Background: Polymyxin-induced nephrotoxicity is a major safety concern in clinical practice due to long-term adverse outcomes and high mortality.
Aim: To conducted a systematic review and meta-analysis of the prevalence and potential predictors of polymyxin-induced nephrotoxicity in adult intensive care unit (ICU) patients.
Methods: PubMed, EMBASE, the Cochrane Library and Reference Citation Analysis database were searched for relevant studies from inception through May 30, 2022.
Article Synopsis
- The study focused on the population pharmacokinetics of colistin sulfate in critically ill adult patients receiving intravenous treatment for over 72 hours, measuring drug concentrations via advanced chromatography techniques.
- A two-compartment model was developed for colistin clearance, identifying creatinine clearance (CrCL) and alanine aminotransferase (ALT) as key factors influencing drug distribution and elimination.
- Monte Carlo simulations indicated that standard dosing regimens were often inadequate for patients with normal kidney function or infections from resistant pathogens, suggesting a need for adjustments based on individual renal function and microbiological susceptibility.