Publications by authors named "Bi-Ru Li"
Article Synopsis
- The study analyzed 45 pediatric patients with hematological neoplasms and acute respiratory distress syndrome (ARDS) admitted to a PICU in Shanghai between 2014 and 2020, focusing on clinical characteristics and outcomes.
- The overall mortality rate was high at 55.6%, with significant differences in clinical indicators like vasoactive inotropic score and pediatric critical illness scoring between survival and non-survival groups.
- It was found that factors like the average fluid volume in the first three days and elevated levels of C-reactive protein and procalcitonin were important predictors of mortality and were associated with more severe cases of ARDS.
Background: Severe sepsis/septic shock with severe neutropenia often leads to poor prognosis. However, it is unknown if severe neutropenia is associated with different clinical outcomes and biomarker features in severe sepsis/septic patients.
Methods: This retrospective cohort study enrolled 141 severe sepsis/septic shock patients admitted to intensive care unit of Shanghai Children's Medical Center between January 2015 and November 2019.
Background: Asparaginase-associated pancreatitis (AAP) is one of the most common complications occurring in patients with asparaginase-treated acute lymphoblastic leukemia (ALL). Peg-asparaginase (peg-asp), a chemically recombined asparaginase with lower hyposensitivity and better patient tolerance, is now approved as the first line asparaginase formulation in ALL chemotherapy regimens. Due to the differences in pharmacokinetic characteristics and administration procedure between l-asp and peg-asp, this study aimed to investigate the clinical manifestations of peg-asp-associated pancreatitis.
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- Immune dysfunction and cytokine storms in SARS-CoV and MERS-CoV patients can worsen the disease, but the exact mechanisms are still unclear and research on vaccines and treatments has been limited.
- SARS-CoV-2, the virus causing COVID-19, shares genetic similarities with SARS-CoV and leads to comparable clinical symptoms, making it a focus for study.
- This review summarizes the immunological traits and clinical aspects of SARS, MERS, and COVID-19, aiming to enhance understanding and inform potential treatment strategies for COVID-19.
Introduction: The aim of this study was to present our 10-year experience of pediatric intensive care unit (PICU) management with pediatric liver recipients and to understand the importance of close interdisciplinary cooperation in 2 hospitals.
Methods: A retrospective chart review study was performed according to our hospital's medical records and the pediatric liver transplant database of Renji hospital.
Results: A total of 767 patients received liver transplantation (LT) performed in Renji hospital between October 2006 and December 2016, of which 97 of them were admitted to PICU in our center for various complications developed after transplantation.
Effect of etanercept on refractory systemic-onset juvenile idiopathic arthritis.
World J Pediatr
February 2016
Background: Treatment of systemic-onset juvenile idiopathic arthritis (So-JIA) is challenging, and the efficacy of injectable recombinant human tumor necrosis factor type 1 receptor-antibody fusion protein (etanercept) on So-JIA has been controversial.
Methods: We retrospectively studied 12 patients with refractory systemic juvenile arthritis treated with etanercept at our hospital in the past 5 years. The 12 patients were divided into a corticosteroid-dependent group (n=7) and an ineffective group (n=5) on the basis of their responses to treatment before the administration of etanercept.
[The protective effect of keratinocyte growth factor on lipopolysaccharide-induced acute lung injury in rat].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
August 2010
Objective: To investigate the protective effect of keratinocyte growth factor (KGF) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and its potential mechanism in rats.
Methods: Thirty-six Sprague-Dawley (SD) rats were randomly divided into three groups, each group with 12 rats. LPS (5 mg/kg) was injected intravenously to induce ALI in model group, and same amount of normal saline was injected in control group and KGF group.
[Value of plasma beta-Glucan in early diagnosis of invasive fungal infection in children].
Zhongguo Dang Dai Er Ke Za Zhi
November 2009
Objective: The incidence of invasive fungal infection (IFI) has risen dramatically along with the prolongation of immunocompromised individuals' lifespan. This study aimed to investigate the incidence of IFI among high risk pediatric patients and to evaluate the diagnostic value of circulating (1,3)-beta-D-glucan (BG) in IFI.
Methods: High risk pediatric inpatients from hemato-oncology department and ICU were enrolled from November 2007 to June 2008.
Background: Hand-foot-mouth disease has become a major public health issue in children in China. In the present prospective study we investigated the clinical characteristics and emergency management of children with severe encephalitis associated with NPE caused by enterovirus 71.
Methods: The study was conducted in 2 pediatric intensive care units (PICUs) over a 2-month period.