Publications by authors named "Bi-Qing Chen"
[Inhibitory Effect of Cinobufotalin on Macrophage Inflammatory Factor Storm and Its Mechanism].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
June 2023
Article Synopsis
- The study aimed to explore how Cinobufotalin affects inflammation in monocytes and activated macrophages, investigating its molecular mechanisms.* -
- THP-1 cells were used to create macrophage activation models, and Cinobufotalin treatment showed a significant reduction in cell proliferation and increased apoptosis, especially in activated macrophages.* -
- Cinobufotalin's anti-inflammatory effects were linked to the inhibition of the TLR4/MYD88/P-IκBa signaling pathway, suggesting its potential for treating diseases related to excessive inflammation.*
[Assay of 18 amino acids in Chuanmingshen violaceum roots by pre-column derivative HPLC].
Zhongguo Zhong Yao Za Zhi
March 2020
The roots of Chuanmingshen violaceum is a commonly used Chinese herb and food, which contains rich amino acids. However, the kinds and amounts of amino acids are variety in this herb among the geographical location and ecological environment. Therefore, this study firstly developed a new pre-column derived HPLC method to quantify the levels of 18 amino acids in Ch.
View Article and Find Full Text PDF[Determination of common dyes in dyed safflower by near infrared spectroscopy].
Zhongguo Zhong Yao Za Zhi
April 2019
Because the red and bright color of corolla is the main indicator for the quality assessment of good safflower,the dyed safflower is sometimes found at the herbal market,what is influence on this herb quality and efficacy. A total of 127 safflower samples was therefore collected from different cultivating areas and herbal markets in China to develop a rapid method to identify the dyed safflower. Near-infrared spectroscopy(NIRS) combined with characteristic identification,high performance liquid chromatography(HPLC),principal component analysis(PCA) and partial least squares regression analysis(PLS) were employed to differentiate safflower from dyed safflower samples,and further quantify the levels of the 6 dyes,i.
View Article and Find Full Text PDFArticle Synopsis
- - Previous research indicated that the NRG1-ErbB4 signaling pathway affects fast-spiking neurons in the frontal cortex and is implicated in the development of primary epilepsy, but its specific function in human symptomatic epilepsy remains unclear.
- - In this study, analysis of human epilepsy tissue revealed elevated levels of NRG1 and ErbB4 in the temporal cortex and showed that NRG1-ErbB4 signaling inhibits the phosphorylation of the GluN2B protein, which is linked to neuron excitability.
- - The findings suggest that the NRG1-ErbB4 pathway plays a crucial role in symptomatic epilepsy, acting as a protective mechanism and differing from its role in primary epilepsy.