Sex difference in lipid levels in first-diagnosed drug-naïve depression patients: A case-control and 12-weeks follow-up study.

Aim: Patients with depression have a high prevalence of developing dyslipidemia. In this study, we aim to investigate the difference of serum lipids, including total cholesterol (TCH), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), between the depressed patients and healthy controls. Sex differences in lipids and their psychological correlations were also included.

[Compositions of organic acids in PM10 emission sources in Xiamen urban atmosphere].

The possible organic acid emission sources in PM10 in Xiamen urban atmosphere such as cooking, biomass burning, vehicle exhaust and soil/dust were obtained using a re-suspension test chamber. A total of 15 organic acids including dicarboxylic acids, fatty acids and aromatic acids were determined using GC/MS after derivatization with BF3/n-butanol. The results showed that the highest total concentration of 15 organic acids (53%) was found in cooking emission and the average concentration of the sum of linoleic acid and oleic acid was 24% +/- 14%.

[1α, 25(OH)(2) D(3) protects pancreatic β-cell line from cytokine-induced apoptosis and impaired insulin secretion].

Objective: To explore the protective effects and potential mechanisms of 1α, 25(OH)(2) D(3) (VitD(3)) on pancreatic β-cells.

Methods: The apoptosis of NIT-1 cells was induced by interleukin-1β (IL-1β) and interferon-γ (IFN-γ) in vitro. Then the apoptotic rate of NIT-1 cells was determined by Hoechest33342 staining and Annexin V-FITC/PI flow cytometry.

[Characteristics of PCBs in a capacitor storage site and an industrial brownfield].

The levels and congener patterns of 28 PCBs compounds were investigated in soil and dust fallout collected in a capacitor storage site and an industrial brownfield, respectively in Sichuan Ziyang Locomotive Factory. The highest concentration of the total PCBs(sigma PCBs =227 502 ng x g(-1)) was found in soil collected from the front gate (unsealed) of the capacitor storage tunnel. Very high levels of sigma PCBs, exceed 10 microg x g(-1), were also found in the dust collected from the window sill of an iron foundry.

[Uncertainty analysis of gas/particle partitioning of atmospheric polycyclic aromatic hydrocarbons].

During the period from August 10, 2010 through August 14, 2010, particle and gas phase PAHs were collected and analyzed using double filters plus PUFs (Poly Urethane Foam) sampling system, and the uncertainties of gas/particle partitioning coefficients of PAHs were investigated using the propagation of errors formulas. The results showed that low-molecular weight PAHs such as naphthalene, acenaphthylene, acenaphthene and fluorene possessed the strong breakthrough capacity with the breakthrough rates close to 50% in double PUF cartridges. The corrected K(p) values based on the sorption of PAHs to the primary filter were more than an order of magnitude higher than those without sorption correction for naphthalene, acenaphthylene and acenaphthene.

Thiazolidinediones protect mouse pancreatic β-cells directly from cytokine-induced cytotoxicity through PPARγ-dependent mechanisms.

Since most of the current studies of thiazolidinediones (TZDs) are only focused on improving glycemic control, increasing insulin sensitivity, and regulating inflammatory states in Type 2 Diabetes, it is still controversial whether TZDs have direct, protective effects on pancreatic β-cells in autoimmune diabetes. Here, we show the protective effects of TZDs on mouse pancreatic β-cell line cells (NIT-1) impaired by exposure to inflammatory cytokines (IL-1β and IFN-γ) and explore the potential mechanisms for this. The apoptosis rate and caspase-3 activity were remarkably increased, and insulin secretion response to glucose was impaired severely by exposure to IL-1β/IFN-γ for 48 h compared to control cells, whereas apoptosis rate and caspase-3 activity were significantly decreased in cells with treatment of rosiglitazone (RGZ) or pioglitazone (PIG), and the capacity for insulin secretion response to glucose was recovered.

[Glitazones protects beta cell function from cytotoxic cytokines through PPAR gamma-dependent mechanisms].

Objective: To investigate the protective effects of glitazones on islet beta cells and PPAR gamma dependence of such effects.

Methods: IL-1beta and IFN-gamma were used to treat NIT-1 cells, a beta cell line, to induce beta cell damage. The cells were pretreated with rosiglitazone and pioglitazone at different concentrations to study the protective effects of these drugs.

[The effect and mechanism of transient continuous subcutaneous insulin infusion therapy on beta cell function, insulin resistance and vascular endothelial injury in newly diagnosed type 2 diabetes].

Objectives: To explore the effect of transient continuous subcutaneous insulin infusion (CSII) on ß cell function, insulin resistance and vascular endothelial injury in newly diagnosed type 2 diabetic patients and its potential mechanism.

Methods: Ten patients with newly diagnosed type 2 diabetes mellitus (T2DM) accepted CSII for two weeks. Intravenous glucose tolerance test (IVGTT) and hyperinsulinemia euglycemia clamp test were performed before and after CSII.

[Inhibitory effects of thiazolidinedione upon cytokine-induced apoptosis in pancreatic beta-cell line].

Objective: To investigate the protective effects and potential mechanisms of TZD upon pancreatic beta-cells.

Methods: Apoptosis was induced in vitro by interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma). After treatment with rosiglitazone (RSG)/pioglitazone (PIG) at the final concentrations of 1 micromol/L, 10 micromol/L, 20 micromol/L respectively, the apoptotic rate of NIT-1 cells was determined by Hoechest33342 staining and Annexin V-FITC/PI flow cytometry respectively.