Publications by authors named "Bi-Jun Qiu"
Background: CD24CK19/CD24SOX9 resident liver cells are activated and expanded after chronic liver injury in a ductular reaction. However, the sources and functions of these cells in liver damage remain disputed.
Results: The current study combined genetic lineage tracing with in vitro small-molecule-based reprogramming to define liver progenitor cells (LPCs) derived from hepatic parenchymal and non-parenchymal tissues.
Article Synopsis
- The study focused on pediatric liver-transplanted patients infected with the Omicron variant BA.2 during the COVID-19 outbreak in Shanghai from March to October 2022.
- Five patients with varying primary diseases showed symptoms like fever upon infection, with the duration of illness lasting around 29 days, categorized as mild to moderate cases.
- Findings indicate that post-transplant immunosuppression can prolong virus clearance and raise the risk of relapse but does not influence the severity or symptom duration; patients often recover well with adjusted immunosuppressant therapy.
Hepatic artery reconstruction in pediatric liver transplantation: Experience from a single group.
Hepatobiliary Pancreat Dis Int
August 2020
Background: The reconstruction of hepatic artery is a challenging part of the pediatric liver transplantation procedure. Hepatic artery thrombosis (HAT) and stenosis are complications which may result in ischemic biliary injury, causing early graft lost and even death.
Methods: Two hundred and fifty-nine patients underwent liver transplantation in 2017 in a single liver transplantation group.
Article Synopsis
- - Pediatric living donor liver transplantation (LDLT) has shown improved survival rates worldwide, but specific data on anesthetic management and postoperative outcomes in China are limited.
- - A study analyzed 544 pediatric LDLT records from Shanghai, revealing high survival rates at 30 days (95.22%), 90 days (93.38%), and 1 year (91.36%), with significant improvements in survival post-2011.
- - Key factors influencing in-hospital and long-term survival included the pediatric end-stage liver disease score, anesthesia and operation durations, intraoperative blood loss, and length of ICU stay.
Objective: To evaluate the efficacy of living-donor liver transplantation (LDLT) in children with tyrosinemia type I.
Methods: Altogether 10 patients diagnosed with tyrosinemia type I underwent LDLT between June 2013 and April 2019. Cirrhosis was the indication for LDLT in all 10 patients, and hepatocellular carcinoma (HCC) was suspected in nine.
Introduction: The aim of this study was to present our 10-year experience of pediatric intensive care unit (PICU) management with pediatric liver recipients and to understand the importance of close interdisciplinary cooperation in 2 hospitals.
Methods: A retrospective chart review study was performed according to our hospital's medical records and the pediatric liver transplant database of Renji hospital.
Results: A total of 767 patients received liver transplantation (LT) performed in Renji hospital between October 2006 and December 2016, of which 97 of them were admitted to PICU in our center for various complications developed after transplantation.
Intrahepatic cholangiocarcinoma is a highly fatal tumor characterized by an abundant stromal environment. Cancer-associated fibroblasts play key roles in tumor growth and invasiveness and have been regarded as a potential therapeutic target. This study was designed to isolate human primary cancer-associated fibroblasts of intrahepatic cholangiocarcinoma to study tumor-stroma interactions and to analyze the clinical relevance of alpha-smooth muscle actin -positive cancer-associated fibroblasts in patients with intrahepatic cholangiocarcinoma.
View Article and Find Full Text PDFMerlin, which is encoded by the tumour suppressor gene Nf2, plays a crucial role in tumorigenesis and metastasis. However, little is known about the functional importance of Merlin splicing forms. In this study, we show that Merlin is present at low levels in human hepatocellular carcinoma (HCC), particularly in metastatic tumours, where it is associated with a poor prognosis.
View Article and Find Full Text PDFBackground & Aims: Due to its anatomic connection, the liver is constantly exposed to gut-derived bacterial products or metabolites. Disruption of gut homeostasis is associated with many human diseases. The aim of this study was to determine the role of gut homeostasis in initiation and progression of hepatocellular carcinoma (HCC).
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