Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A.

mTORC1 is a master regulator of cell growth and proliferation, and an established anticancer drug target. Aberrant mTORC1 signaling is common in hepatocellular carcinoma (HCC), but the underlying mechanism remains elusive. Rab1A is a newly identified mTORC1 activator that mediates an alternative amino acid (AA) signaling branch to Rag GTPases.

[Treatment of premature ovarian failure patients by bushen tiaojing recipe combined hormone replacement therapy: a clinical observation].

Objective: To observe the clinical effect on treatment of premature ovarian failure (POF) patients by Bushen Tiaojing Recipe (BTR) and hormone replacement therapy (HRT).

Methods: Totally 72 POF patients were randomly assigned to three groups by random digit table, i.e.