Publications by authors named "Bi-Hai Li"
The gut microbiota has been demonstrated to play a significant role in the pathogenesis of Parkinson's disease (PD). However, conflicting findings regarding specific microbial species have been reported, possibly due to confounding factors within human populations. Herein, our current study investigated the interaction between the gut microbiota and host in a non-human primate (NHP) PD model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) using a multi-omic approach and a self-controlled design.
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- Recent studies have shown that age significantly influences the gut microbiota, but environmental factors can complicate this relationship, necessitating controlled settings for accurate observation.
- Researchers conducted 16S rRNA gene sequencing to analyze gut microbiota in macaques from infancy to old age in captivity, revealing how it changes throughout life.
- The findings highlighted the rise of certain pathogens in infants and a decline in gut microbial connectivity with age, linking these changes to health and metabolic functions in aging primates.
Background: Excess energy intake contributes to metabolic disorders. However, the relationship between excess sugar and fat in their contributions to metabolic abnormalities remains to be further elucidated. Here we conducted a prospective feeding experiment to evaluate effects of dietary fat-to-sugar ratio on diet-induced metabolic abnormalities in adult cynomolgus monkeys.
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