Publications by authors named "Bi-Fei Cao"
Background And Objectives: Mobility limitations have been linked to cognition. However, little is known about the relationship between mobility decline and cognitive decline. This study investigated the effect of mobility limitations and decline on cognitive decline in a population-based cohort of older adults.
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- Frailty significantly increases the risk of developing chronic liver diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD), cirrhosis, and liver cancer, as well as liver-related mortality.
- A comprehensive study involving over 339,000 participants found that those classified as prefrail or frail had substantially higher risks for these conditions compared to non-frail individuals, based on a follow-up period averaging 11.6 years.
- The findings suggest a need for public health initiatives aimed at reducing the risk of liver diseases in frail populations, emphasizing the importance of addressing frailty in chronic disease management.
Background: It's unclear if excess visceral adipose tissue (VAT) mass in individuals with prediabetes can be countered by adherence to a Mediterranean lifestyle (MEDLIFE). We aimed to examine VAT mass, MEDLIFE adherence, and their impact on type 2 diabetes (T2D) and diabetic microvascular complications (DMC) in individuals with prediabetes.
Methods: 11,267 individuals with prediabetes from the UK Biobank cohort were included.
Background: Healthier lifestyle decreased the risk of mental disorders (MDs) such as depression and anxiety. However, research on the effects of a comprehensive healthy lifestyle on their progression is lacking.
Methods: 385,704 individuals without baseline MDs from the UK Biobank cohort were included.
Background: The human gut microbiota (GM) has been recognized as a significant factor in the development of insomnia, primarily through inflammatory pathways, making it a promising target for therapeutic interventions. Considering the principles of primary prediction, targeted prevention, and personalized treatment medicine (PPPM), identifying specific gut microbiota associated with insomnia and exploring the underlying mechanisms comprehensively are crucial steps towards achieving primary prediction, targeted prevention, and personalized treatment of insomnia.
Working Hypothesis And Methodology: We hypothesized that alterations in the composition of specific GM could induce insomnia through an inflammatory response, which postulates the existence of a GM-inflammation-insomnia pathway.
Background: Arterial stiffness contributes to additional cardiovascular risks in diabetic patients by triggering the loss of vascular and myocardial compliance and promoting endothelial dysfunction. Thus, prevention of arterial stiffness is a public health priority, and the identification of potential biomarkers may provide benefits for early prevention. This study investigates the relationships between serum laboratory tests and pulse wave velocity (PWV) tests.
View Article and Find Full Text PDFBackground: Research on the association of physical activity and sedentary time with dementia is accumulating, though elusive, and the interaction effects of the two remain unclear. We analysed the joint associations of accelerometer-measured physical activity and sedentary time with risk of incident dementia (all-cause dementia, Alzheimer's disease and vascular dementia).
Methods: A total of 90,320 individuals from the UK Biobank were included.