Publications by authors named "Bi-Chen Zhou"
Article Synopsis
- This study focuses on hepatocytes, the main cells in the liver, and explores the essential processes and regulators involved in their maturation.
- Researchers used advanced techniques like single-cell RNA sequencing to identify three distinct stages of postnatal hepatocyte maturation, each linked to specific metabolic functions and varying growth rates.
- The study also uncovered important transcription factors related to maturation and hepatocyte zonation, providing a new framework to understand liver cell development through gene analysis and genetic manipulation.
The effectiveness of multiomics analyses in defining cell differentiation pathways during development is ambiguous. During liver development, hepatoblasts follow a default or directed pathway to differentiate into hepatocytes or cholangiocytes, respectively, and this provides a practical model to address this issue. Our study discovered that promoter-associated histone modifications and chromatin accessibility dynamics, rather than enhancer-associated histone modifications, effectively delineated the "default vs.
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