Photoredox-Catalyzed Aminolactonization of 2-Styrylbenzoic Acids with -Aminopyridinium Salts to Access 4-Sulfonamino-3,4-dihydroisocoumarins.

A photoredox-catalyzed aminolactonization of unsaturated carboxylic acids was achieved using -aminopyridinium salts as the amino radical precursor. The transformation features mild conditions and a remarkably broad substrate scope, offering an efficient approach to construct a wide range of 4-sulfonamino 3,4-dihydroisocoumarins. Mechanistic studies indicate that the reaction proceeds via a distinctive -aminopyridinium salt-promoted electrophilic amination of 2-styrylbenzoic acids.

Deficits in emotional cognition among individuals with conduct disorder: theoretical perspectives.

Conduct disorder refers to a persistent and repetitive pattern of problematic behavior, and is usually accompanied by deficits in cognitive processing of emotional stimuli. Behavioral and physiological correlates of these deficits have been the subject of sufficiently many investigations. Meanwhile, several theories concerning conduct disorder have been developed.

Disruption of Ferroptosis Inhibition and Immune Evasion with Tumor-Activatable Prodrug for Boosted Photodynamic/Chemotherapy Eradication of Drug-Resistant Tumors.

Breast cancer is a malignant tumor that threatens the life and health of women worldwide. As the first-line chemotherapy drug for breast cancer, doxorubicin (DOX) can inhibit the synthesis of RNA and DNA, and it exhibits strong inhibitory activity against breast cancer. However, drug-induced systemic toxicity and drug resistance can occur with DOX treatment.

Growth promotion on maize and whole-genome sequence analysis of D103.

Unlabelled: Root-associated microorganisms, particularly plant growth-promoting rhizobacteria (PGPR) from the genus, play a crucial role in enhancing crop yield and health. In this study, a strain was isolated from the rhizosphere soil of maize and identified as D103. The primary objective of this research was to evaluate the potential of D103 as a PGPR.

Alternative splicing in the genome of HPV and its regulation.

Persistent infection with high-risk human papillomavirus (HR-HPV) is the main cause of cervical cancer. These chronic infections are characterized by high expression of the HPV E6 and E7 oncogenes and the absence of the L1 and L2 capsid proteins. The regulation of HPV gene expression plays a crucial role in both the viral life cycle and rare oncogenic events.

Using the GoogLeNet deep-learning model to distinguish between benign and malignant breast masses based on conventional ultrasound: a systematic review and meta-analysis.

Background: Breast cancer is one of the most common malignancies in women worldwide, and early and accurate diagnosis is crucial for improving treatment outcomes. Conventional ultrasound (CUS) is a widely used screening method for breast cancer; however, the subjective nature of interpreting the results can lead to diagnostic errors. The current study sought to estimate the effectiveness of using a GoogLeNet deep-learning convolutional neural network (CNN) model to identify benign and malignant breast masses based on CUS.

Hippocampal PDHA1 gene knockout inhibits the Warburg effect leading to cognitive dysfunction and attenuates the beneficial effects of ZiBuPiYin recipe on cognition.

Ethnopharmacological Relevance: The attenuation of the Warburg effect is an important pathological feature of cognitive dysfunction, and enhancing the Warburg effect is conducive to improving cognitive function. However, the pathogenic mechanisms underlying cognitive dysfunction remain incompletely elucidated. ZiBuPiYin Recipe (ZBPYR) is a traditional Chinese herbal compound used clinically for the treatment of cognitive dysfunction with significant efficacy.

Causal effects of gut microbiota, metabolites, immune cells, liposomes, and inflammatory proteins on anorexia nervosa: A mediation joint multi-omics Mendelian randomization analysis.

Background: Anorexia nervosa (AN) is a significant psychological disorder influenced by environmental and genetic elements. Emerging research highlights the pivotal role of the gut microbiome in the development of diverse mental health conditions. This study aims to explore the causal effects and interactions of the gut microbiome, metabolites, immune cells, lipids, and inflammatory proteins on the risk of anorexia nervosa through mediation and multi-omics Mendelian Randomization (MR) analysis.

ZiBu PiYin recipe regulates central and peripheral Aβ metabolism and improves diabetes-associated cognitive decline in ZDF rats.

Ethnopharmacological Relevance: Cognitive impairment caused by central neuropathy in type 2 diabetes mellitus (T2DM), namely diabetes-associated cognitive decline (DACD), is one of the common complications in patients with T2DM. Studies have shown that brain β-amyloid (Aβ) deposition is a typical pathological change in patients with DACD, and that there is a close relationship between intestinal microorganisms and cognitive impairment. However, the specific mechanism(s) of alteration in Aβ metabolism in DACD, and of the correlation between Aβ metabolism and intestinal microorganisms remain unknown.

Femtosecond pulse amplification on a chip.

Femtosecond laser pulses enable the synthesis of light across the electromagnetic spectrum and provide access to ultrafast phenomena in physics, biology, and chemistry. Chip-integration of femtosecond technology could revolutionize applications such as point-of-care diagnostics, bio-medical imaging, portable chemical sensing, or autonomous navigation. However, current chip-integrated pulse sources lack the required peak power, and on-chip amplification of femtosecond pulses has been an unresolved challenge.

The mutual influences between working memory and empathy for pain: the role of social distance.

Understanding the mechanisms behind the interaction of empathy for pain (EfP) and working memory (WM), particularly how they are influenced by social factors like perceived social distance (SD), is vital for comprehending how humans dynamically adapt to the complexities of social life. However, there is very little known about these mechanisms. Accordingly, we recruited 116 healthy participants to investigate the bidirectional influence and electrophysiological responses between WM and EfP, including the role of SD.

Heart Diseases Recognition Model Based on HRV Feature Extraction over 12-Lead ECG Signals.

Heart Rate Variability (HRV) refers to the capability of the heart rhythm to vary at different times, typically reflecting the regulation of the heart by the autonomic nervous system. In recent years, with advancements in Electrocardiogram (ECG) signal processing technology, HRV features reflect various aspects of cardiac activity, such as variability in heart rate, cardiac health status, and responses. We extracted key features of HRV and used them to develop and evaluate an automatic recognition model for cardiac diseases.

Angiotensin II depends on hippo/YAP signaling to reprogram angiogenesis and promote liver fibrosis.

Liver fibrosis is a chronic pathological process in which the abnormal proliferation of connective tissue is induced by various pathogenic factors. During the process of fibrosis, excessive angiogenesis is observed. Physiological angiogenesis has the potential to impede the progression of liver fibrosis through augmenting matrix metalloenzyme activity; however, pathological angiogenesis can exacerbate liver fibrosis by promoting collagen accumulation.

Partial rupture of the left main bronchus with left lung atelectasis due to blunt chest injury: a case report.

Background: Bronchial injury is rare in blunt chest trauma, but can be life-threatening. The symptoms of patients with complete bronchial rupture are typical, and most of them are diagnosed in a timely manner and treated with surgery. However, for those with partial rupture of the bronchus, the symptoms are mild, the imaging results are negative, the possibility of delayed diagnosis is high, and serious complications can occur.

Intelligence Mindsets Trajectory Profiles among Chinese Elementary School Students: Associations with Changes in Academic Achievement from Grades 4 to 6.

Early adolescence is a critical period for the development of children's intelligence mindsets, which play a significant role in academic achievement. However, existing research predominantly employs variable-centered approaches, which fail to capture individual differences in mindset-achievement relations. This research addresses this gap by adopting a longitudinal person-centered approach to explore the joint developmental trajectories of growth and fixed mindsets among early adolescents.

Ligand-Enabled Pd-Catalyzed sp C-H Macrocyclization: Synthesis and Evaluation of Macrocyclic Sulfonamide for the Treatment of Parkinson's Disease.

The development of simplified synthetic strategy to create structurally and functionally diverse pseudo-natural macrocyclic molecules is highly appealing but poses a marked challenge. Inspired by natural scaffolds, herein, we describe a practical and concise ligand-enabled Pd(II)-catalyzed sp C-H alkylation, olefination and arylation macrocyclization, which could offer a novel set of pseudo-natural macrocyclic sulfonamides. Interestingly, the potential of ligand acceleration in C-H activation is also demonstrated by an unprecedented enantioselective sp C-H alkylation macrocyclization.

Biomass waste-assisted micro(nano)plastics capture, utilization, and storage for sustainable water remediation.

Micro(nano)plastics (MNPs) have become a significant environmental concern due to their widespread presence in the biosphere and potential harm to ecosystems and human health. Here, we propose for the first time a MNPs capture, utilization, and storage (PCUS) concept to achieve MNPs remediation from water while meeting economically productive upcycling and environmentally sustainable plastic waste management. A highly efficient capturing material derived from surface-modified woody biomass waste (M-Basswood) is developed to remove a broad spectrum of multidimensional and compositional MNPs from water.

Countermeasures and Application Effect of Nursing Interventions in Maintenance Hemodialysis Patients with Complications of Secondary Hyperparathyroidism.

Background: Secondary hyperparathyroidism commonly arises in individuals with end-stage kidney disease, especially those who undergo maintenance hemodialysis (MHD). This study investigated strategies and effectiveness of nursing interventions in MHD patients with secondary hyperparathyroidism complications.

Methodology: This study is a retrospective analysis conducted at the General Hospital of Northern Theater Command.

Trace of delirium after robotic lower abdominal tumor resection at different end-tidal carbon dioxide: a RCT trial.

Background: Postoperative delirium (POD) often occurs in oncology patients, further increasing the medical and financial burden. Robotic technology in lower abdominal tumors resection reduces surgical trauma but increases risks such as carbon dioxide (CO) absorption. This study aimed to investigate the differences in their occurrence of POD at different end-tidal CO levels.

Simple aneuploidy evades p53 surveillance and promotes niche factor-independent growth in human intestinal organoids.

Aneuploidy is nearly ubiquitous in tumor genomes, but the role of aneuploidy in the early stages of cancer evolution remains unclear. Here, by inducing heterogeneous aneuploidy in non-transformed human colon organoids (colonoids), we investigated how the effects of aneuploidy on cell growth and differentiation may promote malignant transformation. Previous work implicated p53 activation as a downstream response to aneuploidy induction.

Organic Cations Texture Zinc Metal Anodes for Deep Cycling Aqueous Zinc Batteries.

Manipulating the crystallographic orientation of zinc (Zn) metal to expose more (002) planes is promising to stabilize Zn anodes in aqueous electrolytes. However, there remain challenges involving the non-epitaxial electrodeposition of highly (002) textured Zn metal and the maintenance of (002) texture under deep cycling conditions. Herein, a novel organic imidazolium cations-assisted non-epitaxial electrodeposition strategy to texture electrodeposited Zn metals is developed.