Multi-scale urban ecosystem service changes and their impact mechanisms on human well-being.

With increasing urbanization pressures, there is an urgent need to improve the urban residents' well-being and achieve the sustainable development goals (SDGs). Ecosystem services (ESs) are vital for human well-being (HW) and survival, providing essential benefits like clean water while supporting the SDGs. However, understanding the impact mechanism of urban ESs on the HW under the framework of the SGDs in a changing world remains challenging.

Hydrogen Sulfide Promotes TAM-M1 Polarization through Activating IRE-1α Pathway via GRP78 S-Sulfhydrylation to against Breast Cancer.

Hydrogen sulfide (HS)-mediated protein S-sulfhydration has been shown to play critical roles in several diseases. Tumor-associated macrophages (TAMs) are the predominant population of immune cells present within solid tumor tissues, and they function to restrict antitumor immunity. However, no previous study has investigated the role of protein S-sulfhydration in TAM reprogramming in breast cancer (BC).

Mn-Doped MCdCl (M = CHNH, CHN, and CHN) Layered Hybrid Perovskite and Its Flexible Film Based on Simple Mechanochemical Synthesis.

Layered hybrid perovskites show significant advantages in the field of optoelectronics. However, the low quantum efficiency and complex preparation methods limit their applications. In this work, we developed a series of perovskite powders with a two-dimensional (2D) layered structure of organic-inorganic hybrid metal halides MCdCl:%Mn (M = CHNH, CHN, CHN) via facile mechanochemical methods.

Enhanced Oxygen Evolution Reaction Performance on NiS@CoO/Nickel Foam Electrocatalysts with Their Photothermal Property.

Based on the principle of heterogeneous catalysis for water electrolysis, electrocatalysts with appropriate electronic structure and photothermal property are expected to drive the oxygen evolution reaction effectively. Herein, amorphous NiS-coupled nanourchin-like CoO was prepared on nickel foam (NiS@CoO/NF) and investigated as a electrocatalyst for photothermal-assisted oxygen evolution reaction. The experimental investigations and simulant calculations jointly revealed NiS@CoO/NF to be of suitable electronic structure and high near-infrared photothermal conversion capability to achieve the oxygen evolution reaction advantageously both in thermodynamics and in kinetics.

First-Principles Calculations on Narrow-Band Gap d Metal Oxides for Photocatalytic H Production: Role of Unusual In Cations in Band Engineering.

The d metal oxides with low effective mass and high mobility of photoexcited electrons have received much attention in photocatalytic water splitting. However, there are still challenges in practical application due to insufficient visible light absorption. Here, an unusual phenomenon of the In cation in PtIn(GeO)O and PtIn(Ga/InO) with a narrow band gap is systematically investigated using density functional theory calculations.

Landslide Susceptibility Evaluation Based on Potential Disaster Identification and Ensemble Learning.

Catastrophic landslides have much more frequently occurred worldwide due to increasing extreme rainfall events and intensified human engineering activity. Landslide susceptibility evaluation (LSE) is a vital and effective technique for the prevention and control of disastrous landslides. Moreover, about 80% of disastrous landslides had not been discovered ahead and significantly impeded social and economic sustainability development.

Stress-Induced Microcracking and Fracture Characterization for Ultra-High-Temperature Ceramic Matrix Composites at High Temperatures.

In this paper, we estimated the temperature-dependent critical inclusion size for microcracking under residual stress and applied stress for particulate-reinforced ultra-high-temperature ceramic matrix composites. The critical flaw size and applied stress for the stable growth of radial cracks under different temperatures were also estimated. It was found that under a lower applied stress, the critical inclusion size was sensitive to the temperature.

Highly Stable Orange-Red Long-Persistent Luminescent CsCdCl :Mn Perovskite Crystal.

Halide perovskite has been widely studied as a new generation of photoelectronic materials. However, their thermal and humidity-induced emission quenching have greatly limited their utility and reliability. Here, we report a hexagonal Mn -doped CsCdCl perovskite crystal that possesses stable photoluminescence (PL) at both high temperature and humidity.

Effects of Preparation Methods on the Microstructure and Mechanical Properties of Graphene-Reinforced Alumina Matrix Composites.

Recent years have witnessed a growing research interest in graphene-reinforced alumina matrix composites (AlO-G). In this paper, to better achieve the dispersion of graphene in composites, a ball milling method for adding raw materials step by step, called stepwise feeding ball milling, was proposed. The AlO-1.

Computational Recognition of a Regulatory T-cell-specific Signature With Potential Implications in Prognosis, Immunotherapy, and Therapeutic Resistance of Prostate Cancer.

Prostate cancer, recognized as a "cold" tumor, has an immunosuppressive microenvironment in which regulatory T cells (Tregs) usually play a major role. Therefore, identifying a prognostic signature of Tregs has promising benefits of improving survival of prostate cancer patients. However, the traditional methods of Treg quantification usually suffer from bias and variability.

Hollow InVO Nanocuboid Assemblies toward Promoting Photocatalytic N Conversion Performance.

The unique InVO mesocrystal superstructure, particularly with cubical skeleton and hollow interior, which consists of numerous nanocube building blocks, closely stacking by stacking, aligning by aligning, and sharing the same crystallographic orientations, is successfully fabricated. The synergy of a reaction-limited aggregation and an Ostwald ripening process is reasonably proposed for the growth of this unique superstructure. Both single-particle surface photovoltage and confocal fluorescence spectroscopy measurements demonstrate that the long-range ordered mesocrystal superstructures can significantly retard the recombination of electron-hole pairs through the creation of a new pathway for anisotropic electron flow along the inter-nanocubes.

Development of a Novel Prognostic Signature Based on Antigen Processing and Presentation in Patients with Breast Cancer.

Complex antigen processing and presentation processes are involved in the development and progression of breast cancer (BC). A single biomarker is unlikely to adequately reflect the complex interplay between immune cells and cancer; however, there have been few attempts to find a robust antigen processing and presentation-related signature to predict the survival outcome of BC patients with respect to tumor immunology. Therefore, we aimed to develop an accurate gene signature based on immune-related genes for prognosis prediction of BC.

lncRNA-Xist/miR-101-3p/KLF6/C/EBPα axis promotes TAM polarization to regulate cancer cell proliferation and migration.

The phenotypic switch in tumor-associated macrophages (TAMs) mediates immunity escape of cancer. However, the underlying mechanisms in the TAM phenotypic switch have not been systematically elucidated. In this study, long noncoding RNA (lncRNA)-Xist, CCAAT/enhancer-binding protein (C/EBP)α, and Kruppel-like factor 6 (KLF6) were upregulated, whereas microRNA (miR)-101 was downregulated in M1 macrophages-type (M1).

Pan-cancer analysis of NLRP3 inflammasome with potential implications in prognosis and immunotherapy in human cancer.

NLRP3 inflammasome was introduced as a double-edged sword in tumorigenesis and influenced immunotherapy response by modulating host immunity. However, a systematic assessment of the NLRP3-inflammasome-related genes across human cancers is lacking, and the predictive role of NLRP3 inflammasome in cancer immunotherapy (CIT) response remains unexplored. Thus, in this study, we performed a pan-cancer analysis of NLRP3-inflammasome-related genes across 24 human cancers.

Prognostic alternative splicing signature reveals the landscape of immune infiltration in Pancreatic Cancer.

Pancreatic cancer (PC) is an aggressive cancer with worse survival in the world. Emerging evidence suggested that the imbalance of alternative splicing (AS) is a hallmark of cancer and indicated poor prognosis of patients. Genes-derived splicing events can produce neoepitopes for immunotherapy.

A five-mRNA signature associated with post-translational modifications can better predict recurrence and survival in cervical cancer.

High mortality of patients with cervical cancer (CC) stresses the imperative of prognostic biomarkers for CC patients. Additionally, the vital status of post-translational modifications (PTMs) in the progression of cancers has been reported by numerous researches. Therefore, the purpose of this research was to dig a prognostic signature correlated with PTMs for CC.

Glycolysis gene expression profilings screen for prognostic risk signature of hepatocellular carcinoma.

Metabolic changes are the markers of cancer and have attracted wide attention in recent years. One of the main metabolic features of tumor cells is the high level of glycolysis, even if there is oxygen. The transformation and preference of metabolic pathways is usually regulated by specific gene expression.

Intrinsic adriamycin resistance in p53-mutated breast cancer is related to the miR-30c/FANCF/REV1-mediated DNA damage response.

Adriamycin(ADR) is still considered to be one of the most effective agents in the treatment of breast cancer (BrCa), its efficacy is compromised by intrinsic resistance or acquire characteristics of multidrug resistance. At present, there are few genetic alterations that can be exploited as biomarkers to guide targeted use of ADR in clinical. Therefore, exploring the determinants of ADR sensitivity is pertinent for their optimal clinical application.

SNORD89 promotes stemness phenotype of ovarian cancer cells by regulating Notch1-c-Myc pathway.

Background: Ovarian cancer is the leading cause of death in gynecological cancer. Cancer stem cells (CSCs) contribute to the occurrence, progression and resistance. Small nucleolar RNAs (SnoRNAs), a class of small molecule non-coding RNA, involve in the cancer cell stemness and tumorigenesis.

Ferroelectric Polarization-Enhanced Photocatalysis in BaTiO-TiO Core-Shell Heterostructures.

Suppressing charge recombination and improving carrier transport are key challenges for the enhancement of photocatalytic activity of heterostructured photocatalysts. Here, we report a ferroelectric polarization-enhanced photocatalysis on the basis of BaTiO-TiO core-shell heterostructures synthesized via a hydrothermal process. With an optimal weight ratio of BaTiO to TiO, the heterostructures exhibited the maximum photocatalytic performance of 1.

MFG-E8 overexpression is associated with poor prognosis in breast cancer patients.

Background: MFG-E8(Milk fat globule-EGF factor 8), a secreted glycoprotein, plays an exceptional role in various diseases. MFG-E8 overexpression is found in a variety of cancers. However, it remains unclear whether MFG-E8 overexpression is associated with the clinicopathological characteristics and prognosis of human breast cancer.

Prognostic relevance of miR-137 and its liver microenvironment regulatory target gene AFM in hepatocellular carcinoma.

MiR-137 has been identified as potential hepatocellular carcinoma (HCC) prognostic biomarkers. Highly relevant HCC prognostic biomarkers may be derived from combinations of miR-137 with its target genes involved in the regulation of liver microenvironment. This study aimed at the discovery of such a combination with improved HCC prognosis performance than miR-137 or its target gene alone in a significantly higher number of HCC patients than previous studies.

High PITX1 expression in lung adenocarcinoma patients is associated with DNA methylation and poor prognosis.

Background: Pituitary homeobox 1 (PITX1) is a member of the PITX gene family which is vital to proper development of early embryo. However, the relationship of PITX1 expression and overall survival (OS) in non-small cell lung cancer (NSCLC) is not clear.

Methods: In our study, bioinformatic analysis was performed using UCSC Xena Browser.