[Acupuncture based on "status-target coherence" theory combined with Kegel exercises for vaginal laxity syndrome: a randomized controlled trial].

Objective: To observe the clinical efficacy of acupuncture based on "status-target coherence" theory combined with Kegel exercises for vaginal laxity syndrome (VLS).

Methods: Sixty-six patients with VLS were randomized into an observation group (33 cases, 2 cases dropped out, 1 case was discontinued) and a control group (33 cases, 5 cases dropped out). The observation group was treated with acupuncture combined with Kegel exercises, acupuncture was applied to bilateral Ciliao (BL32), Zhongliao (BL33), Sanyinjiao (SP6), etc.

Correction: Yu et al. The Role of circTmeff-1 in Morphine Addiction Memory of Mice. 2023, , 1985.

In the original publication [...

The role of gene polymorphisms in lung adenocarcinoma susceptibility and lipid profile.

Background: APOE gene polym orphisms have been linked to Alzheimer's disease and coronary heart diseases. However, their relationship with lung adenocarcinoma (LUAD) remains uncertain.

Methods: This study analyzed a cohort of 600 individuals comprising 200 LUAD patients in the lung cancer group and 400 healthy individuals as controls.

A novel strategy based on the dielectric barrier discharge plasma for rapid elimination of the carryover associated with μPESI-MS/MS system.

Image 1.

Clinical Characteristics, Risk Factors and Outcomes of Invasive Fungal Disease in Critically III Patients with Hematological Malignancy: A Retrospective Study.

Background: Invasive fungal disease (IFD) poses significant challenges for critically ill patients with hematological malignancies (HMs). However, there is limited research on the clinical characteristics, risk factors, and outcomes of IFD within this population.

Method: A retrospective study was conducted at a tertiary center in China.

Transcranial alternating current stimulation inhibits ferroptosis and promotes functional recovery in spinal cord injury via the cGMP-PKG signalling pathway.

Aims: This study explores the potential of neuromodulation, specifically transcranial alternating current stimulation (tACS), as a promising rehabilitative therapy in spinal cord injury (SCI).

Main Methods: By meticulously optimizing treatment parameters and durations, our objective was to enhance nerve regeneration and facilitate functional recovery. To assess the efficacy of tACS, our experiments used the rat T10 SCI model.

Whole-genome resequencing reveals collagen-related genes in Kele pigs.

Objective: To verify the accuracy of collagen-specific SNP mutation loci of Kele pigs selected by whole genome resequencing, and to excavate collagen-related genes of Kele pigs, so as to lay a foundation for further molecular selection.

Methods: Based on whole genome resequencing, candidate genes related to collagen trait of Kele pig were screened for gene annotation. Through KEGG and GO enrichment analysis of differential genes, we selected four genes that may affect collagen trait of collagen pig, namely COL9A1, COL6A5, COL4A3 and COL4A4.

Preliminary exploration of metagenomic sequencing for pathogenic identification in infectious uveitis.

Purpose: To evaluate the advantages and clinical utility of metagenomic sequencing (MGS) in diagnosing infectious uveitis pathogens.

Methods: A retrospective study was conducted on 20 infectious uveitis patients (20 eyes) who received treatments at the Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine from May 2020 to February 2021. Anterior aqueous humor of the patients was collected and analyzed using MGS.

The research focus and frontiers in surgical treatment of essential tremor.

Background: Essential tremor (ET) is one of the most prevalent neurodegenerative disorders, with surgery serving as the principal treatment option. This paper presents a bibliometric analysis of research in the field of ET surgery from 2004 to 2024, aiming to identify current research hotspots and inform future research directions.

Methods: This study employs CiteSpace to analyze publication trends, countries/institutions, authors, keywords, and co-cited references in ET surgery, using the Web of Science core database from 2004 to 2024 to delineate the research pathways.

Toward High-Performance Pure-Green Tandem Organic Light-Emitting Diodes by Employing Barrier-Free Strategies in the Charge Generation Layer.

Charge generation layers (CGLs) play crucial roles in determining the electroluminescence (EL) performance of tandem organic light-emitting diodes (OLEDs). However, acquiring negligible voltage drops across the CGL unit and high-efficiency multiplications remains challenging. Here, we propose barrier-free strategies to compose a high-performance p-i-n type CGL intermediate by introducing a Yb/HI-9 modification at the heterojunction and a novel n-dopant, Yb:1,3-bis(9-phenyl-1,10-phenanthrolin-2-yl)benzene (mdPPhen), as the n-CGL.

Molecular Customization of Anode-Electrolyte Interfaces for Enhanced Stability and Reversibility in Aqueous Zinc-Carbon Capacitors.

Aqueous zinc-carbon capacitors display application potential in green power and high-end equipment owing to their high security, large power and sustainability. The water-rich zinc anode-electrolyte interface (AEI) and disordered zinc-ion diffusion are the culprits triggering corrosion reactions and dendrite growth, threatening the sustainability of aqueous zinc-carbon capacitors. Herein, a polyfunctional biomolecular, vitamin B6, is introduced into the traditional aqueous electrolyte for customizing the functional AEI and fine-regulating the interfacial coordination environment of zinc ions.

Heterogeneous graph contrastive learning with gradient balance for drug repositioning.

Drug repositioning, which involves identifying new therapeutic indications for approved drugs, is pivotal in accelerating drug discovery. Recently, to mitigate the effect of label sparsity on inferring potential drug-disease associations (DDAs), graph contrastive learning (GCL) has emerged as a promising paradigm to supplement high-quality self-supervised signals through designing auxiliary tasks, then transfer shareable knowledge to main task, i.e.

Positive Selection of TLR2 and MyD88 Genes Provides Insights Into the Molecular Basis of Immunological Adaptation in Amphibians.

The transition from water to land of amphibians is evolutionarily significant in the history of vertebrates, and immunological adaptation is an important challenge for amphibians to respond to the dramatic changes of the environmental pathogens during their origin and diversification. Toll-like receptors (TLRs) are important pattern recognition receptors for the innate immune response and TLRs signaling pathway play essential roles in the immune responses to pathogens and inflammatory reaction. However, the evolutionary patterns and molecular mechanisms underlying their adaptation in amphibians are poorly documented to date.

Effect of Alkali Source on Crystal Regulation and Ethanol Gas Sensing Properties of Nano-ZnO.

This study investigates the ethanol gas-sensing mechanisms of ZnO nanocrystals with distinct morphologies, synthesized via a hydrothermal method using various alkali sources. Significant differences in the gas-sensing performance and morphology of ZnO samples synthesized with ammonium carbonate (NaCO), hexamethylenetetramine (HMTA), ammonia solution (NH·HO), and sodium hydroxide (NaOH) were observed. ZnO were confirmed to be impurity-free through XRD analysis, and their morphological features were characterized by SEM.

Therapeutic Efficacy and Underlying Mechanisms of a Mannoglucan from Mycelium on Dextran Sulfate Sodium-Induced Inflammatory Bowel Disease in Mice: Modulation of the Intestinal Barrier, Oxidative Stress and Gut Microbiota.

, a non-sexual form of the valuable Chinese medicinal herb, demonstrates various biological activities, such as immune modulation and antioxidative capabilities. Nonetheless, the effects of bioactive polysaccharides derived from on colitis have yet to be investigated. In our prior research, we extracted a mannoglucan (HSWP-1d) from and found that it attenuates TGF-β1-induced epithelial-mesenchymal transition.

The landscape of alternative splicing in granulosa cells and a potential novel role of YAP1 in PCOS.

Polycystic ovary syndrome (PCOS) is a prevalent yet complex reproductive endocrine disorder affecting 11-13% of women worldwide. Its main symptoms include elevated androgen levels, irregular menstrual cycles, and long-term metabolic and offspring health implications. Despite the disease's multifaceted nature involving genetic, epigenetic, and environmental factors, the role of alternative splicing in ovarian granulosa cells remains relatively unexplored.

Internet-based cognitive behavioral therapy for anxiety and depression in breast cancer survivors: a meta-analysis.

Objective: Evaluating the effects of Internet-based cognitive behavioral therapy (I-CBT) on anxiety and depression in breast cancer (BC) survivors.

Methods: Systematic searches were conducted on eight Chinese and English databases from inception to July 20, 2024, for relevant randomized controlled trials. The quality of included trials was evaluated using the Cochrane risk of bias (ROB 2.

Effects of acupuncture at limb Acupoints-Guangming (GB37) on UDVA, CS, and EEG microstate in myopia.

Introduction: Acupuncture is beneficial in improving visual function for myopi periocular acupoints Taiyang can improve contrast sensitivity (CS). In this study, we aim to further investigate the impact of acupuncture at the limbs acupoints-Guangming(GB37) acupoint on visual function, and the neural mechanism of acupuncture at the GB37 acupoint improving visual function through electroencephalography (EEG) microstate.

Methods: A total of 22 myopia were recruited.

Inhibitory effect of Zhujing Pill on myopia progression: Mechanistic insights based on metabonomics and network pharmacology.

Objectives: This study endeavored to uncover the mechanisms by which Zhujing pill (ZJP) slows myopia progression.

Methods: We employed biometric analyses to track diopter and axial length changes in guinea pigs with negative lens-induced myopia (LIM). Through integrating metabonomics and network pharmacology, we aimed to predict the anti-myopic targets and active ingredients of ZJP.

Development and Validation of a Sensitive LC-MS/MS Method for Determination of Lenvatinib and Its Major Metabolites in Human Plasma and Its Application in Hepatocellular Carcinoma Patients.

Lenvatinib has been demonstrated effective in advanced hepatocellular carcinoma (HCC), but the pharmacokinetic-pharmacodynamics behavior of lenvatinib and its metabolites remains unclear. To investigate the pharmacokinetic-pharmacodynamics behavior of lenvatinib and its active metabolites in advanced HCC patients, it is important to develop a simple and rapid method to analyze the exposures of lenvatinib and its metabolites in human samples. Here, we established and validated a simple and rapid method for determining lenvatinib and its three major metabolites, descyclopropyl lenvatinib (M1), O-demethyl lenvatinib hydrochloride (M2), and lenvatinib N-Oxide (M3) by liquid chromatography-tandem mass spectrometry method.

Abnormal tRNA epigenetic modifications and related impact on neurodegenerative diseases.

Neurodegenerative diseases are a heterogeneous group of neurological disorders characterized by the progressive loss of neurons in the central or peripheral nervous system. Research on the pathogenesis and drug targets of these diseases still faces many challenges due to the complex etiology. In recent years, the role of transfer RNA (tRNA) epigenetic modifications in neurodegenerative diseases has attracted widespread attention.

Ultra-stable metal-organic framework-derived carbon nanocontainers with defect-induced pore enlargement for anti-corrosive epoxy coatings.

Zeolitic imidazolate frameworks-8 (ZIF-8) have recently gained attention as nanocontainers for encapsulating corrosion inhibitors. However, two main challenges remain unsolved, casting doubt on their suitability as nanocontainers. The first challenge is their instability in acidic and basic environments, leading to structural decomposition and the second challenge is their mass diffusion limitation caused by micropore dominance and a small aperture size of 0.

Quantitative Trait Loci Mapping for Powdery Mildew Resistance in Wheat Genetic Population.

Powdery mildew is a prevalent wheat disease that affects yield and quality. The characterization and fine mapping of genes associated with powdery mildew resistance can benefit marker-assisted breeding. In this study, quantitative trait loci (QTL) associated with powdery mildew were mapped using a high-density 35K DArT genetic linkage map developed from a population of double haploid lines (DHs) created by crossing "Jinmai 33 (a highly resistance line) with Yannong 19 (a highly susceptible line)".