Caregiver-centric interventions for family carers of children with neurodevelopmental disorders in India - A scoping review.

Caregiving for children with neurodevelopment disorders (NDDs) can be a lifelong process that takes hold of an individual's time, energy, and resources. This raises a question about the caregivers' needs and concerns and the extent to which they receive medical or psychological attention during caregiving. This scoping review examines the psychosocial interventions conducted in India for caregivers of children with NDDs.

Expressed Emotion in Families of Children with Neurodevelopmental Disorders: A Mixed-Method Approach.

Background: Family interaction plays a pivotal role in the overall well-being of each member of a family unit. It is foreseeable that a family caring for an individual with a mental or physical health condition could experience negative family interactions for various reasons. Expressed emotion refers to the family environment based on the relatives' interaction with the individual diagnosed with a specific illness.

Impact of Moving Walls and Entropy Generation on Doubly Diffusive Mixed Convection of Casson Fluid in Two-Sided Driven Enclosure.

In this study, numerical simulations are conducted with the goal of exploring the impact of the direction of the moving wall, solute and thermal transport, and entropy production on doubly diffusive convection in a chamber occupied by a Casson liquid. Wall movement has a significant impact on convective flow, which, in turn, affects the rate of mass and heat transfer; this sparked our interest in conducting further analysis. The left and right (upright) walls are preserved with constant (but different) thermal and solutal distributions, while the horizontal boundaries are impermeable to mass transfer and insulated from heat transfer.

FDA-Approved Chimeric Antigen Receptor (CAR)-T Cell Therapy for Different Cancers-A Recent Perspective.

Cancer is one of the most prevalent diseases in the world, and their rate of occurence has been increased in recent decades. Current review article, summarizes the novel treatment options Chimeric Antigen Receptor-T (CAR-T) cell therapy for various cancers constitute a major health and development challenge, impacting every aspect of sustainable development quoted by goal 3 good health and well-being of UN sustainable goals. WHO estimates that 70% of cancer deaths occur in low- and middle- income countries (LMICs) by 2030, LMICs are expected to bear the brunt of the expected 24.

Assessment of Pulp Vitality in Multirooted Teeth With Advanced Periodontal Disease: A Clinical and Histological Study.

Background/purpose: The relationship between endodontic and periodontal lesions remains a controversy. Their diagnosis is often difficult and requires an interdisciplinary approach to rule out the cause and provide appropriate treatment. Periodontitis as an etiology of pulpal necrosis and irreversible pulpitis has been a hypothetical concept.

Estimation of salivary lactate dehydrogenase in oral squamous cell carcinoma, oral leukoplakia, and smokers.

Introduction: Lactate dehydrogenase (LDH) is an enzyme seen within every cell during their normal metabolic function. It is always confined within the cell cytoplasm and it becomes extracellular only when a cell dies. The extracellular presence of LDH is related to cell necrosis and tissue breakdown.

Investigating the Lung Adenocarcinoma Stem Cell Biomarker Expressions Using Machine Learning Approaches.

The objective of the study is to look at the activation of stem cell-related markers in lung adenocarcinoma. Utilizing an unsupervised machine learning approach centered on the mRNA expression of pluripotent stem cells as well as its subsequent developed progeny, the mRNA stemness index of further around 500 LUAD patients from The Cancer Genome Atlas dataset was generated. In LUADs, mRNAsi had first been investigated using differential variations, survivability analyses, medical phases, and sexuality.

Molecular insights of hyaluronic acid - ethambutol and hyaluronic acid - isoniazid drug conjugates act as promising novel drugs for the treatment of tuberculosis.

The present study examines cellular targeted drug delivery (CTDD) pattern of two novel Hyaluronic acid (HA) Tuberculosis Drug (TB) conjugates and its efficacy and strong binding affinity towards TB molecular protein targets. Two TB drugs ethambutol (EB) and isoniazid (IN) and their Hyaluronic acid conjugates (HA-EB & HA-IN) were tested for its metabolism, toxicity and excretion prediction through tools they revealed hyaluronic acid conjugate of two TB drugs exhibited good drug profile over their free form of TB drugs. Further these four molecules subjected to molecular docking study with four potential target proteins (3PD8, 4Y0L, 5DZK and 6GAU).

Role of diet and lifestyle modification in the management of nonalcoholic fatty liver disease and type 2 diabetes.

Nonalcoholic fatty liver disease (NAFLD) is considered as the hepatic evidence of insulin resistance which is the hallmark of type 2 diabetes. NAFLD is considered as the risk factor for developing type 2 diabetes and has a high frequency of occurrence in those with existing type 2 diabetes. Compared with patients with only NAFLD or type 2 diabetes, these patients show a poor metabolic profile and increase mortality.

Numerical Simulation on Convection and Thermal Radiation of Casson Fluid in an Enclosure with Entropy Generation.

The goal of the current numerical simulation is to explore the impact of aspect ratio, thermal radiation, and entropy generation on buoyant induced convection in a rectangular box filled with Casson fluid. The vertical boundaries of the box are maintained with different constant thermal distribution. Thermal insulation is executed on horizontal boundaries.

In vitro and in vivo efficacy of rosmarinic acid on quorum sensing mediated biofilm formation and virulence factor production in Aeromonas hydrophila.

Rosmarinic acid (RA) was assessed for its quorum sensing inhibitory (QSI) potential against Aeromonas hydrophila strains AH 1, AH 12 and MTCC 1739. The pathogenic strains of A. hydrophila were isolated from infected zebrafish and identified through biochemical analysis and amplification of a species-specific gene (rpsL).

Assessment of Psychological and Psycho-physiological Problems Among Visually Impaired Adolescents.

Background: Visual impairment tends to evoke more discomfiture than any other disability. Primarily, the biggest issue may be that blindness is visible. Furthermore, visual impairment develops serious medical, psychological, social and economic problems.

Structure of Sesbania mosaic virus at 3 A resolution.

Sesbania mosaic virus (SMV) is an isometric, ss-RNA plant virus found infecting Sesbania grandiflora plants in fields near Tirupathi, South India. The virus particles, which sediment at 116 S at pH 5.5, swell upon treatment with EDTA at pH 7.

Primary structure of sesbania mosaic virus coat protein: its implications to the assembly and architecture of the virus.

Sesbania mosaic virus (SMV) is a plant virus that infects Sesbania grandiflora plants in Andhra Pradesh, India. The amino acid sequence of the coat protein of SMV was determined using purified peptides generated by cleavage with trypsin, chymotrypsin, V8 protease and clostripain. The 230 residues so far determined were compared to the corresponding residues of southern bean mosaic virus (SBMV), the type member of sobemoviruses.