Efficacy and Safety of Bisphosphonates in Chronic Non-bacterial Osteomyelitis of the Mandible: A Systematic Review.

Chronic non-bacterial osteomyelitis (CNO) of the mandible, often called diffuse sclerosing osteomyelitis (DSO) in Maxillofacial and Dental literature, is a rare condition characterized by sterile osteomyelitis affecting the mandible. This condition is part of the chronic recurrent multifocal osteomyelitis (CRMO)/synovitis, acne, pustulosis, hyperostosis, and osteomyelitis (SAPHO) spectrum. However, because mandibular involvement may present as unifocal disease, it deserves special attention.

Comparative evaluation of three accidentally extruded sealers in periapical healing - An evidence - based study.

Background: The present study aimed to evaluate the periapical healing of root canal treatment after accidental extrusion and rate of resorption of three different base endodontic sealers.

Materials And Methods: Seventy-five patients with single visit root canal treated teeth with accidental extrusion of sealer were selected based on inclusion and exclusion criteria and were allocated into three equal groups based on different base endodontic sealers used during obturation; Grossman, Sealapex™, and Seal-pex. Radiographic evaluation was done to assess periapical healing and rate of resorption at baseline, 1, 3, and 6 months.