Efforts toward the first total synthesis of a mixed-ligand siderophore: Gobichelin-A.

The synthesis of Gobichelin-A, a naturally occurring mixed-ligand siderophore isolated from Streptomyces sp. NRRL F-4415, is described. The target molecule was planned to be synthesized by a convergent process involving the combination of two halves, Gob-A 1st half and Gob-A 2nd half, at the prefinal stage of the synthetic route.

Comprehensive review on natural pharmacophore tethered 1,2,3-triazoles as active pharmaceuticals.

The privileged 1,2,3-triazole scaffold is drawing researcher's attention due to its widespread applications in diverse fields such as drug discovery (e.g., carboxyamidotriazole), organic synthesis (click-reaction template), polymeric materials (e.

Synthesis and antioxidant activity of a new class of bis and tris heterocycles.

A series of novel heterocycles, bisbenzoxazolyl/benzothiazolyl/benzimidazolyl pyrazoles/isoxazoles/pyrimidines were synthesized and evaluated for their antioxidant activity. The bisbenzoxazolylisoxazole 10 exhibited good antioxidant activity when compared with the standard ascorbic acid.

The reactivity of gem cyanoester ketene dithiolates towards the development of potent antioxidant heterocycles.

The reactivity of gem cyanoester ketene dithiolates towards the development of a variety of heterocycles was studied and tested for antioxidant property. The compounds bis benzoxazolylmethylthiomethylene pyrazoles and isoxazoles displayed excellent radical scavenging activity when compared with the standard ascorbic acid.

One-pot synthesis of 5-[[Bis(azolylmethylthio)]methylene]pyrimidine-2,4,6-(1H,3H,5H)-triones.

A new class of hitherto unknown trisheterocycles, bisoxadiazolyl/bisthiadiazolyl pyrimidinetriones/thioxopyrimidinediones was prepared in a one-pot reaction and their antimicrobial activity was studied.