Publications by authors named "Bhrugumalla S"
Article Synopsis
- The study investigates the use of diffusion-weighted imaging (DWI) to effectively diagnose focal liver lesions and differentiate between benign and malignant types, particularly focusing on metastases versus primary tumors.
- Conducted on 28 patients with ultrasound-detected liver lesions, the research utilized both DWI and contrast-enhanced MRI (CE-MRI) to analyze lesion characteristics, confirmed through histopathological examination.
- The findings revealed that out of 44 lesions studied, 54.5% were benign and 45.45% malignant, with DWI demonstrating 85% sensitivity and 84.7% specificity in distinguishing these lesions.
Article Synopsis
- Acute pancreatitis (AP) is a common reason for hospital stays and is linked to worse outcomes in obese patients, particularly those with high visceral fat.
- This study assessed the relationship between visceral adiposity and the severity of AP by measuring the visceral adipose tissue (VAT) area in patients admitted with the condition.
- Results showed that individuals with severe pancreatitis had larger VAT areas, suggesting that VAT could be a useful predictor of AP severity, warranting further research into its role as a prognostic indicator.
Article Synopsis
- Staging cancer accurately is essential for treatment, and 18F-FDG PET/CT imaging is a common tool used to identify potentially cancerous areas.
- However, benign conditions can also cause false-positive results, such as anthracosis leading to enlarged lymph nodes, which can be mistaken for cancer spread in patients with existing malignancies.
- The article discusses six cases where benign anthracotic lymphadenitis was wrongly identified during cancer staging, with a recommendation for endosonography-guided tissue acquisition to clarify these cases.
Background: Common bile duct (CBD) stones are known to complicate 10-15% of gallstone diseases. Endoscopic retrograde cholangiopancreatography (ERCP) is the therapeutic modality of choice for bile duct clearance in CBD stones but may fail to achieve stone clearance. This prospective study was done to identify the predictors of failure of CBD clearance with ERCP.
View Article and Find Full Text PDFBackground: Endoscopic ultrasound (EUS)-guided cystogastrostomy is the treatment of choice for managing symptomatic pancreatic fluid collections (PFC). However, studies on the number of stents for optimal drainage of PFCs are limited. Hence, the present study was conducted to compare the outcome of single versus two double-pigtail stents for endoscopic drainage of PFCs.
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- Tuberculosis (TB) is a significant risk for patients with autoimmune diseases receiving anti-TNF therapies, particularly in TB-endemic countries like India, and this study focuses on understanding this risk in patients with inflammatory bowel disease (IBD).
- The study analyzed data from 95 IBD patients treated with anti-TNF agents, primarily infliximab, over a median follow-up of 9 months, finding that 8.4% developed TB, mostly extrapulmonary cases.
- The duration of anti-TNF therapy emerged as the sole independent predictor for TB development, highlighting limitations in current latent TB screening methods in India and the challenges of predicting TB in these patients.
Background: Tissue acquisition from a thickened gastric wall using biopsy forceps may not always lead to diagnosis, given the submucosal location of the pathology. Endoscopic ultrasound (EUS)-guided tissue acquisition (TA) may serve as a minimally invasive diagnostic tool in such cases. Hence, we aimed to assess the diagnostic outcome and safety of EUS-TA from thickened gastric walls.
View Article and Find Full Text PDFObjectives: Tofacitinib is a Janus Kinase inhibitor used for treating moderate to severe ulcerative colitis (UC), mainly after the failure of biological therapy. There is a paucity of data on the outcome of tofacitinib in biological-naïve UC patients. The present study was aimed at analyzing the safety and efficacy of tofacitinib in biological-naïve Indian patients with UC.
View Article and Find Full Text PDFBackground: Both Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT) have been linked to various prothrombotic (PT) conditions. The PT profile in Asians is different from the west and there are no nationwide epidemiological surveys from India. Hence, the present meta-analysis was aimed at analyzing the prevalence of acquired and hereditary thrombophilia among Indian patients with non-cirrhotic PVT and BCS.
View Article and Find Full Text PDFBackground: Endoscopic ultrasound (EUS)-guided tissue acquisition is the preferred modality for diagnosing pancreatic lesions and mediastinal and abdominal lymph nodes. Rapid on-site cytologic evaluation improves the diagnostic outcome of EUS-guided fine-needle aspiration (FNA) but is unavailable at many centers. Alternatively, macroscopic on-site evaluation (MOSE) may improve the diagnostic outcome of EUS-FNA, but data are limited.
View Article and Find Full Text PDFBackground: The diagnosis of intraparenchymal lung masses is challenging when lesions are located at sites inaccessible through bronchoscopy or endobronchial ultrasound. Endoscopic ultrasound (EUS)-guided tissue acquisition (TA)-fine-needle aspiration (FNA) or fine-needle biopsy-provides a potentially useful diagnostic tool for lesions located adjacent to the esophagus. This study was conducted to analyze the diagnostic outcome and safety of EUS-guided tissue sampling of lung masses.
View Article and Find Full Text PDFAim Of The Study: Endoscopic variceal ligation (EVL) is important for emergency as well as prophylactic management of esophageal varices. Early bleeding after EVL is associated with significant morbidity and mortality. Assessing the likelihood of early post-EVL bleeding and its determinants can help deciding therapeutic strategies for high-risk patients.
View Article and Find Full Text PDFObjectives: Hepatitis B virus (HBV) infection during pregnancy is associated with perinatal transmission contributing to the pool of HBV infection in the population. There is a wide variation in the reported data on the seroprevalence of HBV in pregnant patients from various parts of India. Hence, a systematic review and meta-analysis was conducted to determine the pooled seroprevalence of HBV and its associated demographic factors.
View Article and Find Full Text PDFAn array of pathophysiological processes can lead to chronic nausea and vomiting, including gastrointestinal and non-gastrointestinal disorders. Initial symptoms of adrenal insufficiency are usually non-specific, but intractable nausea and vomiting are infrequently associated, posing a diagnostic dilemma for clinicians. Here we present such a patient, who responded to glucocorticoid replacement with complete improvement.
View Article and Find Full Text PDFAim: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the world today. A previous study has suggested an association of apolipoprotein C3 (APOC3) gene variants with the risk of NAFLD in Asian Indian men living in the Western regions. The present study was carried out with an aim to evaluate the association of demographic features, serum lipid profile and APOC3 gene variants (C-482T and T-455C) NAFLD.
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