Porous Pd-Loaded IRMOF-9 as Highly Efficient Recyclable Material Towards the Reduction of Nitroaromatics in Aqueous Media.

Nitroaromatic compounds (NACs) cause severe hazardous impacts on human health as well as on the environment. Therefore, there is dire need to develop a robust material to reduce the toxicity of these organic pollutants. In this regard, our group developed a series of porous MOF materials viz.

Highly Efficient Cauliflower-like Palladium-Loaded Porous MOF as a Robust Material for the Degradation of Organic Dyes.

A series of porous MOF materials, viz., Pd@IRMOF-9 ( = 2, 5, and 10%) were synthesized by loading varying concentrations of Pd(II) on IRMOF-9. The synthesized MOF materials were characterized by ltravioletisible (UV-Vis) spectroscopy, Fourier transform Infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), Brunauer-Emmett-Teller (BET), and scanning electron microscopy (SEM) analyses.

Dog-bone shaped gold nanoparticle-mediated chemo-photothermal therapy impairs the powerhouse to trigger apoptosis in cancer cells.

The mitochondrion has emerged as one of the uncommon targets in cancer therapeutics due to its involvement in cancer generation and progression. Consequently, nanoplatform mediated delivery of anti-cancer drugs into the mitochondria of cancer tissues demonstrated immense potential in cancer treatment. In the last couple of decades, gold nanoparticles have gained incredible attention in biomedical applications due to their easy synthesis, size-shape tenability, optical properties and outstanding photothermal ability.

Coumarin-Calix[4]arene Conjugate-Anchored SiO Nanoparticles as an Ultrasensor Material for Fe to Work in Water, in Serum, and in Biological Cells.

A coumarin-appended calixarene derivative ( ) and a hybrid material generated by covalently linking this onto a silica surface ( ) were synthesized and were characterized by various analytical, spectroscopy, and microscopy methods. Both these materials are capable of sensing Fe with greater sensitivity and selectivity. The sensitivity is enhanced by 30,000 fold on going from a simple solution phase to the silica surface with the limit of Fe detection being 1.

Calixarene-Assisted Pd Nanoparticles in Organic Transformations: Synthesis, Characterization, and Catalytic Applications in Water for C-C Coupling and for the Reduction of Nitroaromatics and Organic Dyes.

A new type of ternary hybrid, Pd@MCM-Calix, based on mesoporous silica, calixarene conjugate, and Pd(0) nanoparticles (NPs) was synthesized by sacrificial oxidation of allylic calixarene conjugate eventually functionalized with mesoporous silica without using any external reducing agent. The role of the calix conjugate in the formation of Pd@MCM-Calix has been established. The hybrid, Pd@MCM-Calix, was characterized by different techniques to support the formation of well-dispersed Pd(0) NPs of 12 ± 2 nm size.

Physicochemical and Ion-Sensing Properties of Benzofurazan-Appended Calix[4]arene in Solution and on Gold Nanoparticles: Spectroscopy, Microscopy, and DFT Computations in Support of the Species of Recognition.

A calix[4]arene conjugate () functionalized at the lower rim with a benzofurazan fluorophore (NBD) and at the upper rim with a thioether moiety has been synthesized and characterized by H NMR, C NMR, and mass spectrometry techniques. Both the absorption and emission spectral data for in different solvents exhibited progressive changes with an increase in polarity. Ion recognition studies were performed by absorption and fluorescence spectroscopy using 10 different metal ions.

Fluorescent Lower Rim 1,3-Dibenzooxadiazole Conjugate of Calix[4]arene in Selective Sensing of Fluoride in Solution and in Biological Cells Using Confocal Microscopy.

p- tert-Butyl-calix[4]arene was derivatized by integrating a benzooxadiazole fluorescent tag into its 1,3-arms at the lower rim to result in L and was characterized. L was titrated with 17 anions in THF and found selective for F ions with lowest detection limit of 109 ppb. L and F form a 1:1 complex.

Silica-Calix Hybrid Composite of Allyl Calix[4]arene Covalently Linked to MCM-41 Nanoparticles for Sustained Release of Doxorubicin into Cancer Cells.

An inorganic-organic hybrid material, MCM-allylCalix, was synthesized by covalent modification of an MCM-41 surface with a tetra-allyl calixarene conjugate. The synthesized hybrid was characterized by C and Si MAS-NMR, Fourier transform infrared (FT-IR), Brunauer-Emmett-Teller surface area, thermogravimetric analysis (TGA), and transmission electron microscopy (TEM) analyses. The application of this MCM-allylCalix hybrid has been demonstrated for loading and in vitro release of doxorubicin (Dox) in phosphate-buffered saline (PBS) buffer as well as in the cancer cells, viz.