Semiconductor quantum dots for photodynamic therapy: Recent advances.

Photodynamic therapy is a promising cancer treatment that induces apoptosis as a result of the interactions between light and a photosensitizing drug. Lately, the emergence of biocompatible nanoparticles has revolutionized the prospects of photodynamic therapy (PDT) in clinical trials. Consequently, a lot of research is now being focused on developing non-toxic, biocompatible nanoparticle-based photosensitizers for effective cancer treatments using PDT.

Targeting Breast Cancer and Their Stem Cell Population through AMPK Activation: Novel Insights.

Despite some significant advancements, breast cancer has become the most prevalent cancer in the world. One of the main reasons for failure in treatment and metastasis has been attributed to the presence of cancer initiating cells-cancer stem cells. Consequently, research is now being focussed on targeting cancer cells along with their stem cell population.

Anticancer Activity of Urease Mimetic Cobalt (III) Complexes on A549-Lung Cancer Cells: Targeting the Acidic Microenvironment.

Tumour cells maintain a local hypoxic and acidic microenvironment which plays a crucial role in cancer progression and drug resistance. Urease is a metallohydrolases that catalyses the hydrolysis of urea into ammonia and carbon dioxide, causing an abrupt increase of pH. This enzymatic activity can be employed to target the acidic tumour microenvironment.

Reactivity trends of cobalt(III) complexes towards various amino acids based on the properties of the amino acid alkyl chains.

The reactivity of the cobalt(III) complexes dichlorido[tris(2-aminoethyl)amine]cobalt(III) chloride, [CoCl(tren)]Cl, and dichlorido(triethylenetetramine)cobalt(III) chloride, [CoCl(trien)]Cl, towards different amino acids (L-proline, L-asparagine, L-histidine and L-aspartic acid) was explored in detail. This study presents the crystal structures of three amino acidate cobalt(III) complexes, namely, (L-prolinato-κN,O)[tris(2-aminoethyl)amine-κN,N',N'',N''']cobalt(III) diiodide monohydrate, [Co(CHNO)(CHN)]I·HO, I, (L-asparaginato-κN,O)[tris(2-aminoethyl)amine-κN,N',N'',N''']cobalt(III) chloride perchlorate, [Co(CHNO)(CHN)](Cl)(ClO), II, and (L-prolinato-κN,O)(triethylenetetramine-κN,N',N'',N''')cobalt(III) chloride perchlorate, [Co(CHNO)(CHN)](Cl)(ClO), V. The syntheses of the complexes were followed by characterization using UV-Vis spectroscopy of the reaction mixtures and the initial rates of reaction were obtained by calculating the slopes of absorbance versus time plots.

The crystal structure of the zwitterionic co-crystal of 2,4-di-chloro-6-{[(3-hy-droxy-prop-yl)azaniumyl]-meth-yl}phenolate and 2,4-di-chloro-phenol.

The title compound, CHClNO·CHClO, was formed from the incomplete Mannich condensation reaction of 3-amino-propan-1-ol, formaldehyde and 2,4-di-chloro-phenol in methanol. This resulted in the formation of a co-crystal of the zwitterionic Mannich base, 2,4-di-chloro-6-{[(3-hy-droxy-prop-yl)azaniumyl]-meth-yl}phenolate and the unreacted 2,4-di-chloro-phenol. The compound crystallizes in the monoclinic crystal system (in space group ) and the asymmetric unit contains a mol-ecule each of the 2,4-di-chloro-phenol and 2,4-di-chloro-6-{[(3-hy-droxy-prop-yl)azaniumyl]-meth-yl}phenolate.

Energetic propane-1,3-diaminium and butane-1,4-diaminium salts of N,N'-dinitroethylenediazanide: syntheses, crystal structures and thermal properties.

The acidity of the amine H atoms and the consequent salt formation ability of ethylenedinitramine (EDNA) were analyzed in an attempt to improve the thermal stability of EDNA. Two short-chain alkanediamine bases, namely propane-1,3-diamine and butane-1,4-diamine, were chosen for this purpose. The resulting salts, namely propane-1,3-diaminium N,N'-dinitroethylenediazanide, CHN·CHNO, and butane-1,4-diaminium N,N'-dinitroethylenediazanide, CHN·CHNO, crystallize in the orthorhombic space group Pbca and the monoclinic space group P2/n, respectively.

Vanadium(V) complexes of a tripodal ligand, their characterisation and biological implications.

The reaction of the tripodal tetradentate dibasic ligand 6,6'-(2-(pyridin-2-yl)ethylazanediyl)bis(methylene)bis(2,4-di-tert-butylphenol), H2L(1)I, with [V(IV)O(acac)2] in CH3CN gives the V(V)O-complex, [V(V)O(acac)(L(1))] 1. Crystallisation of 1 in CH3CN at ∼0 °C gives dark blue crystals of 1, while at room temperature it affords dark green crystals of [{V(V)O(L(1))}2μ-O] 3. Upon prolonged treatment of 1 in MeOH, [V(V)O(OMe)(MeOH)(L(1))] 2 is obtained.

Palladium(II) complexes of OS donor N-(di(butyl/phenyl)carbamothioyl)benzamide and their antiamoebic activity.

Two promising palladium(II) compounds of general formula, cis-[Pd(L-O,S)2] [where HL-O,S = N-(di(butyl/phenyl)carbamothioyl)benzamide] as metal based antiamoebic drug candidates, have been synthesized. Both complexes are characterized in the solid state by FT-IR spectroscopy, TGA and single crystal X-ray study, as well as in solution by other spectroscopic techniques such as (1)H and (13)C NMR, and UV-visible. All these studies confirm the coordination of ligands through oxygen and sulphur atoms upon thioenolization induced delocalization.