Publications by authors named "Bhawna Attri"
Purpose Of Review: Postprandial hyperglycemia, or elevated blood glucose after meals, is associated with the development and progression of various diabetes-related complications. Prandial insulins are designed to replicate the natural insulin release after meals and are highly effective in managing post-meal glucose spikes. Currently, different types of prandial insulins are available such as human regular insulin, rapid-acting analogs, ultra-rapid-acting analogs, and inhaled insulins.
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- The study assessed cost-effective and non-invasive methods for diagnosing ACTH-dependent Cushing's syndrome (CS), aiming to replace more invasive approaches like BIPSS and peripheral CRH stimulation.
- Using ROC analysis, the researchers identified optimal cut-off values for various tests and constructed non-invasive models that achieved 100% positive predictive value (PPV) for detecting Cushing's disease (CD).
- These models allowed 41% of patients with ACTH-dependent CS and no macroadenoma to bypass BIPSS, and 22% to skip peripheral CRH stimulation, enabling direct referral for pituitary surgery.
Article Synopsis
- Endogenous Cushing's syndrome (CS) can lead to secondary osteoporosis and vertebral fractures even with normal bone mineral density (BMD); thus, the study aimed to analyze BMD and trabecular bone score (TBS) in CS patients compared to healthy controls.
- The study included 40 women with endogenous CS and 40 matched healthy controls, measuring biochemical parameters, BMD, and TBS.
- Results showed that CS patients had significantly lower BMD and TBS values than controls, with some patients having normal BMD but low TBS, indicating that TBS is a valuable tool for assessing bone health in these patients.
Context: Late-night salivary cortisol (LNSC) is a simple and reliable screening test for Cushing syndrome (CS). With improved analytical performance of the current second-generation electrochemiluminescence immunoassay (ECLIA; Elecsys Cortisol-II; Roche Diagnostics), there is a need to revisit the LNSC cut-offs, especially in a South-Asian population.
Objective: To derive LNSC cut-offs for diagnosis of CS using second-generation ECLIA kits.
Purpose: We aimed to evaluate and compare the clinical, biochemical and radiological profile and outcomes of patients with ectopic ACTH syndrome (EAS) and Cushing disease (CD) treated over a period of 10 years (2013-2022).
Methods: In this ambispective observational study, we collected data for 146 patients with ACTH-dependent CS (EAS, n = 23; CD, n = 94; occult ACTH source, n = 29). Relevant details were filled in a predesigned proforma and outcomes were ascertained at the most recent visit.
Cushing's syndrome due to primary pigmented nodular adrenal disease in two brothers with Carney complex.
Pediatr Endocrinol Diabetes Metab
September 2021
Two brothers (19 and 18 years old, respectively) presented with weight gain and stunted growth since the age of 10 years. They had spotty skin pigmentation over the face along with florid features of Cushing's syndrome with low bone density, renal calculi, dyslipidaemia, hypertension, and dilated cardiomyopathy. They underwent evaluation of the hypothalamic-pituitary-adrenals axis, which suggested ACTH-independent Cushing's syndrome, and the abdominal CT imaging revealed normal adrenals.
View Article and Find Full Text PDFBackground And Aim: The coronavirus disease 2019 (COVID-19) outbreak has rapidly crossed international boundaries and placed increasing demands on healthcare facilities worldwide. Patients with diabetes and uncontrolled blood glucose levels are at increased risk for poor clinical outcomes and in-hospital mortality related to COVID-19. Therefore, achieving good glycaemic control is of paramount importance among hospitalised patients with COVID-19.
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