Publications by authors named "Bhawana Dikshit"
Article Synopsis
- * A significant percentage (≥39%) of GBM tumors exhibit increased levels of FAT1 and various markers related to epithelial-mesenchymal transition (EMT) and stemness, reflecting a strong positive correlation between FAT1 expression and these markers.
- * Reducing FAT1 levels in GBM cells lowered EMT and stemness markers, highlighting FAT1's unique regulatory role that operates both through and independently of the hypoxia-related protein HIF-1α, suggesting FAT1 could be
The hypoxic microenvironment is an important contributor of glioblastoma (GBM) aggressiveness via HIF1α, while tumour inflammation is profoundly influenced by FAT Atypical Cadherin (FAT1). This study was designed to explore the functional interaction and significance of FAT1 and HIF1α under severe hypoxia-mimicking tumour microenvironment in primary human tumours. We first identified a positive correlation of FAT1 with HIF1α and its target genes in GBM tumour specimens, revealing the significance of the FAT1-HIF1α axis in glioma cells.
View Article and Find Full Text PDFHypoxia is a hallmark of solid tumors including glioblastoma (GBM). Its synergism with Notch signaling promotes progression in different cancers. However, Notch signaling exhibits pleiotropic roles and the existing literature lacks a comprehensive understanding of its perturbations under hypoxia in GBM with respect to all components of the pathway.
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