Gaucher-like cells in a granular cell tumor.

The macrophages in connective tissue stroma and the tumor cells of granular cell tumors have many histochemical features similar to those of Gaucher cells. Ultrastructural examination of a granular cell tumor revealed the stromal cells to contain inclusions of various sizes and shapes. These inclusions, which contained macrophages, greatly resembled the Gaucher-like cells seen in various hematologic conditions and in lobomycosis.

Simultaneous occurrence of intradermal nevus and syringoma.

A 59-year-old white woman presented with two lesions on her face. A clinical diagnosis of intradermal nevus was made and the lesions were excised. In each lesion, histopathologic examination showed an intradermal nevus associated with syringoma.

Keratinocyte damage in vitiligo.

Light and electron-microscopic studies were performed on the amelanotic and adjacent normal-appearing skin in patients with vitiligo. The amelanotic skin revealed complete loss of pigment and absence of melanocytes. In addition to severe degenerative changes of melanocytes, varying degree of damage was also seen in the keratinocytes of normal-appearing skin adjacent to amelanotic skin.

Steroid-induced 'granulomas' in hypertrophic scar.

Intralesional steroids injected into hypertrophic scars and keloids can result in histiocytic and foreign body granulomatous reaction which may be confused with focal mucinosis or necrobiotic process such as rheumatoid nodule. An awareness of this possibility might avoid unnecessary investigations in the patient.

Histiocytic lymphoma and malignant angioendotheliomatosis: one disease or two?

The case history of a patient with diffuse histiocytic lymphoma and skin lesions characteristic of malignant angioendotheliomatosis is reported. The patient initially responded to aggressive chemotherapy but quickly had a relapse, CNS disease developed, and the patient died one year after diagnosis. Microscopic, ultrastructural, and surface membrane studies showed that the intravascular tumor cells were not of endothelial origin.

Diverse familial malignant tumors and Epstein-Barr virus.

Continued monitoring of a family for new malignant tumors has revealed diverse immunological and neoplastic disorders during a 15-year period. In 1966, the proband developed lymphoma. In 1975, his antibody titers to Epstein-Barr virus (EBV) became elevated, and again, he developed a malignant lymphoma.

Leukemia cutis in blastic transformation of chronic myelocytic leukemia: TdT positive blasts and response to vincristine and prednisone.

A patient with chronic myelocytic leukemia (CML) in blast transformation with extensive involvement of the skin is reported. The leukemic infiltrates consisted of blasts with lymphoblastoid morphology which were positive for terminal deoxynucleotidyl transferase (TdT) by fluorescent assay. The infiltrates rapidly resolved with vincristine and prednisone therapy.

Junctions of endoplasmic reticulum and virus like intranuclear inclusions and virus like intranuclear inclusions in amelanotic melanoma metastatic to the jejunum.

Antemortem diagnosis of amelanotic metastatic melanoma to jejunum was made in a 35-year-old white man, who is still alive and healthy. Electron microscopy, in addition to finding premelanosomes, revealed virus-like intranuclear inclusions. Nuclear pockets and junctions of endoplasmic reticulum were also observed.

Charcot-Marie-Tooth disease associated with hypertrophic neuropathy: a neuropathologic study of two cases.

The neuropathologic features of two cases of Charcot-Marie-Tooth disease associated with hypertrophic neuropathy are described. The peripheral nerves had a loss of myelinated fibers, endoneurial fibrosis, and numerous onion-bulb formations. The most severe changes were seen in the distal nerves.

Microcirculatory changes in posttraumatic pigmented villonodular synovitis.

The synovium from a case of pigmented villonodular synovitis was examined by light and electron microscopy. The hyperplastic villous processes were found to contain, besides many blood vessels, a dense population of phagocytic cells actively engulfing and digesting the erythrocytes; some of their phagosomes ("siderosome") contained iron-laden micelles sometimes arranged in a crystalline lattice. The synovial vessels were remarkable in two respects: first, there was evidence of endothelial breakdown; second, the basement membranes were strikingly multilayered.

Cellular blue nevus. An ultrastructural study.

Cellular blue nevus can be clinically and histogenetically confused with malignant melanoma but remains a benign neoplasm of uncertain histogenesis. This paper reports the ultrastructural features of three cases of cellular blue nevus and emphasizes melanosomal alterations, including immature and granular forms, multiple layers of basement membrane around vessels, nerve fibers and tumor cells; endothelial fenestrations and banded structures within the nerve and outside in the stroma. A unifying concept of neural crest derived tumors is presented to better understand the histogenesis of cellular blue nevus.

Tactile-like structures in neurofibromas. An ultrastructural study.

The light- and electron-microscopic features of four neurofibromas are described. In each case, whorled structures resembling tactile corpuscles were observed. Ultrastructurally, these lamellated formations were composed predominantly of perineurial cells, although many had a "central core" containing either a myelinated or unmyelinated axon, or several Schwann cells unassociated with axons.

Pilar sheath acanthoma. A new benign follicular tumor.

Pilar sheath acanthoma is a recently recognized entity. The tumor is a benign follicular neoplasm, occurring on the skin of the upper lip. This paper reports the 10th recorded case.

Combined melanocytoma-mastocytoma in a case of nodular mastocytosis.

A patient with long-standing nodular mastocytosis developed a slate-blue lesion on the scalp which produced symptoms of histamine release on mechanical and thermal stimulation. Light and electron microscopic examination of the lesion showed zones of mast cells and zones of melanized cells. A transition zone showing cells with dual (melanosomal and mast) granulation, as well as granules representing intergrades between classical mast granules and melanosomes, was present.

Becker's melanosis: an ultrastructural study.

Becker's melanosis is an uncommon condition characterized by hypertrichosis, hyperpigmentation of the epidermis, dermal melanophages and absence of nevus cells. Ultrastructural examination of such a melanotic lesion from a young white man revealed giant melanosomes. In addition, normal-sized melanosomes were found singly in the keratinocytes of the involved skin.