Publications by authors named "Bhavyata Pandya Shesh"
Article Synopsis
- * Anemia was linked to reduced median overall survival in males but not in females, suggesting a potential difference in how anemia affects survival based on sex.
- * Iron supplementation in anemic females showed a trend toward improved survival, though not statistically significant, while no such benefit was observed in anemic males, highlighting the complexity of iron biology in glioblastoma patients.
Purpose: Iron plays a crucial role in various biological mechanisms and has been found to promote tumor growth. Recent research has shown that the H-ferritin (FTH1) protein, traditionally recognized as an essential iron storage protein, can transport iron to GBM cancer stem cells, reducing their invasion activity. Moreover, the binding of extracellular FTH1 to human GBM tissues, and brain iron delivery in general, has been found to have a sex bias.
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- Iron is crucial for cancer cell survival, and glioblastoma initiating cells (GICs) have a high demand for iron, prompting research into ferritin as a potential iron source.
- H-ferritin was shown to bind to human GBM tissues and its uptake by GICs was linked to reduced invasiveness, particularly through the action of the protein Rap1A.
- The study concludes that H-ferritin plays a significant role in iron acquisition for GBMs and that increased iron delivery can lead to decreased invasion capabilities of GICs.
Since its discovery more than 85 years ago, ferritin has principally been known as an iron storage protein. However, new roles, beyond iron storage, are being uncovered. Novel processes involving ferritin such as ferritinophagy and ferroptosis and as a cellular iron delivery protein not only expand our thinking on the range of contributions of this protein but present an opportunity to target these pathways in cancers.
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