Use of Synthetic Membranes and Bovine Blood in Artificial Feeding Systems of Mosquitoes Improves Feeding Rates: Results from a Systematic Review and Meta-Analysis.

Artificial blood feeding of mosquitoes is essential for their rearing in insectaries as well as for mosquito-borne pathogen transmission experiments. We conducted a systematic review and meta-analysis of the different artificial feeding systems available for mosquitoes to synthesize evidence regarding their efficacy in terms of feeding rates and fecundity. PubMed, Scopus, Web of Science, and Google Scholar were systematically searched to retrieve 1,822 experimental studies assessing the efficacy of artificial feeding systems.

Metagenomic Analysis Reveals the Complex Microbial Landscape of Market Chicken Meat.

Unlabelled: The safety of meat from a microbiological standpoint is of paramount concern to public health, given the potential for bacterial contaminants to grow and persist during processing and storage. To address this issue, a culture-independent approach targeting the V3-V4 region of the gene was utilized to investigate the inherent bacterial communities present in 10 chicken meat samples obtained from retail markets. Amplicons were sequenced using the Illumina MiSeq platform, and unique amplicon sequence variants (ASVs) were identified using the DADA2 pipeline.

Longitudinal multi-trajectory phenotypes of severe eosinophilic asthma on type 2 biologics treatment.

Background: Limited understanding exists regarding the progression trajectory of severe eosinophilic asthma (SEA) patients on type 2 biologics therapies.

Objective: We aim to explore distinct longitudinal phenotypes of these patients based on crucial asthma biomarkers.

Methods: We enrolled 101 adult patients with SEA.

Microplastic contamination in Indian rice: A comprehensive characterization and health risk assessment.

In this study, we investigate, for the first time, the abundance, distribution, chemical composition, and exposure of microplastics (MPs) in Indian rice and their impact on human health. The physical and chemical characteristics of MPs were measured using a stereomicroscope, μ-Fourier transform infrared spectroscopy, and μ-Raman spectroscopy. MPs were identified in all samples, with an average abundance of 30.

Awareness about Orthodontists' Role in Treating Osa and Mouth Breathing among Otolaryngologists.

Background: Orthodontic correction of dentofacial abnormalities is a crucial component of oral health because it enhances overall oral health-related quality of life, optimal function, periodontal health, and aesthetics. This study sought to determine whether otolaryngologists recommend patients to orthodontists, whether they are adequately knowledgeable about the fundamentals of orthodontics, and whether they check for orthodontic problems in their patients.

Materials And Method: We conducted a survey study of otolaryngologists in Gujarat, India.

A Survey on Awareness Regarding Certain Common Craniofacial Deformities and its Treatment Approach Among Gujarat Population.

The leading intent of the present questionnaire is to assess the ratio of the concerned population as well as the treatment approach of craniofacial deformities among Gujarat citizenry. The theme of Google Form was used for 100 partakers to record responses via sending the questionnaire in English and Gujarati languages through WhatsApp and Emails. From the 100 respondents which are from laymen of Gujarat, 62.

A Questionnaire-based Survey of Postgraduate Students on Awareness about Direct Printed Aligners.

Aims And Objectives: The purpose of this survey was to assess postgraduate students' knowledge of orthodontic direct printed aligners and their opinions of the treatment modalities that can be used with them.

Materials And Methods: 198 postgraduate learners were given a questionnaire consisting of 25 questions via Google Forms as part of this web-based survey. Results: Compared to their male counterparts, women were more knowledgeable about direct printed aligners.

Stress Attributes for Indian Orthodontic Practitioners: A Cross-sectional Study.

Background: Because orthodontists work long hours and maintain a relationship with each patient for many years prior to the end of treatment, they may encounter unusually stressful situations.

Materials And Methods: A self-administered, anonymous survey was disseminated to orthodontic residents and practitioners in India. The survey includes 29 probable stressors.

Effect of biologic therapies on quality of life in severe asthma: Findings from the PRISM study.

Background: Anti-type 2 (T2) biologic therapies (biologics) improve exacerbation rates, lung function, and asthma-related quality of life (QoL) in patients with severe T2 asthma. However, studies comparing different biologics are lacking. We evaluated the QoL in patients with severe asthma comprehensively and compare the efficacy of different T2-directed biologics using QoL questionnaires.

Integrative proteome analysis of bone marrow interstitial fluid and serum reveals candidate signature for acute myeloid leukemia.

Acute myeloid leukemia (AML) is an aggressive form of blood cancer and clinically highly heterogeneous characterized by the accumulation of clonally proliferative immature precursors of myeloid lineage leading to bone marrow failure. Although, the current diagnostic methods for AML consist of cytogenetic and molecular assessment, there is a need for new markers that can serve as useful candidates in diagnosis, prognosis and understanding the pathophysiology of the disease. This study involves the investigation of alterations in the bone marrow interstitial fluid and serum proteome of AML patients compared to controls using label-free quantitative proteomic approach.

One Health Risk and Disease (OHRAD): a tool to prioritise the risks for epidemic-prone diseases from One Health perspective.

Background: The rise in epidemic-prone diseases daily poses a serious concern globally. Evidence suggests that many of these diseases are of animal origin and contribute to economic loss. Considering the limited time and other resources available for the animal and human health sectors, selecting the most urgent and significant risk factors and diseases is vital, even though all epidemic-prone diseases and associated risk factors should be addressed.

Musical Neurofeedback Advancements, Feedback Modalities, and Applications: A Systematic Review.

The field of EEG-Neurofeedback (EEG-NF) training has showcased significant promise in treating various mental disorders, while also emerging as a cognitive enhancer across diverse applications. The core principle of EEG-NF involves consciously guiding the brain in desired directions, necessitating active engagement in neurofeedback (NF) tasks over an extended period. Music listening tasks have proven to be effective stimuli for such training, influencing emotions, mood, and brainwave patterns.

The prowess of metabolomics in cancer research: current trends, challenges and future perspectives.

Cancer due to its heterogeneous nature and large prevalence has tremendous socioeconomic impacts on populations across the world. Therefore, it is crucial to discover effective panels of biomarkers for diagnosing cancer at an early stage. Cancer leads to alterations in cell growth and differentiation at the molecular level, some of which are very unique.

Predictors of Early and Late Lung Function Improvement in Severe Eosinophilic Asthma on Type2-Biologics in the PRISM Study.

Background: The determinants linked to the short- and long-term improvement in lung function in patients with severe eosinophilic asthma (SEA) on biological treatment (BioT) remain elusive.

Objective: We sought to identify the predictors of early and late lung function improvement in patients with SEA after BioT.

Methods: 140 adult patients with SEA who received mepolizumab, dupilumab, or reslizumab were followed up for 6 months to evaluate improvement in forced expiratory volume in one second (FEV).

Exploring private sector perspectives on barriers and facilitators in availing tuberculosis care cascade services: a qualitative study from the Indian state.

Introduction: The private sector plays an important role in tuberculosis (TB) elimination by providing access to quality TB care services like diagnosis and treatment, advocacy for preventive measures, innovation to address challenges in TB elimination, vaccines etc. The study aims to understand the perspectives of private practitioners on patients' TB care cascade to reinforce existing interventions by assuring the quality of care to TB patients.

Methods: The study utilized a qualitative design through in-depth interviews of private practitioners and was conducted in Ranchi and Purbi Singhbhum District of Jharkhand State from March-August 2021.

Proteomic signatures of eosinophilic and neutrophilic asthma from serum and sputum.

Background: Eosinophilic and neutrophilic asthma defined by high levels of blood and sputum eosinophils and neutrophils exemplifies the inflammatory heterogeneity of asthma, particularly severe asthma. We analysed the serum and sputum proteome to identify biomarkers jointly associated with these different phenotypes.

Methods: Proteomic profiles (N = 1129 proteins) were assayed in sputum (n = 182) and serum (n = 574) from two cohorts (U-BIOPRED and ADEPT) of mild-moderate and severe asthma by SOMAscan.

Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome.

Background: Delay in type II alveolar epithelial cell (AECII) regeneration has been linked to higher mortality in patients with acute respiratory distress syndrome (ARDS). However, the interaction between Doublecortin-like kinase 1 (DCLK1) and the Hippo signaling pathway in ARDS-associated AECII differentiation remains unclear. Therefore, the objective of this study was to understand the role of the DCLK1/Hippo pathway in mediating AECII differentiation in ARDS.

Deaths among tuberculosis patients of the western state of India: A secondary record based analytical study on its determinants.

Introduction: India has a significant TB burden, and ongoing attempts are being made to eradicate the disease. Globally, the number of TB deaths is declining, but not quickly enough to meet the End TB Goals. The National Strategic Plan (NSP) 2017-2025 in India set in motion an ambitious effort to expand the scope and efficacy of the National Tuberculosis Elimination Program (NTEP).

Effective multi-stage biodegradation of commercial bulk polyurethane by Clonostachys and Purpureocillium spp.

Dealing with plastic waste in an environmentally friendly and effective manner has been a conundrum that much research has attempted to address. An attractive approach is biodegradation by microorganisms; however microorganisms that have shown such potential are generally only able to degrade surface layers of polymer materials. Herein we describe the multi-stage degradation of commercial bulk polyurethane by two strains of fungi isolated from a landfill.

Child and Caregiver Beliefs of Importance of Physical Function and Quality of Life in Juvenile Idiopathic Arthritis: A Survey Study.

Purpose: To evaluate patient-caregiver beliefs of relative importance across 4 domains while living with juvenile idiopathic arthritis (JIA).

Methods: This was a cross-sectional, anonymous survey study conducted in an academic medical center. Participants with JIA and caregivers (N = 151) completed a Likert-style survey to rate items by importance of knowledge about 4 domains: medications, physical activity, routine measures, and quality of life.

Keratose Self-Cross-Linked Wound Dressing for Iron Sequestration in Chronic Wounds.

Chronic wound diseases affect a large part of the world population, and therefore, novel treatments are becoming fundamental. People with chronic wounds show high iron and protease levels due to genetic disorders or other comorbidities. Since it was demonstrated that iron plays an important role in chronic wounds, being responsible for oxidative processes (ROS generation), while metalloproteinases prevent wound healing by literally "eating" the growing skin, it is crucial to design an appropriate wound dressing.

Dissecting WASH Assessment Tools and Recommending a Comprehensive Tool for Indian Healthcare Facilities.

Providing adequate Water Sanitation and Hygiene (WASH) in Health Care Facilities (HCFs) has many benefits, including achieving Sustainable Development Goals (SDGs) and Universal Health Coverage (UHC). However, there is a significant shortage of statistics on the status of WASH in Healthcare Facilities (WinHCF), resulting in roadblocks in developing improvement strategies. Further, there is a lack of detailed comparison of WASH components covered in available tools against the standards.