Publications by authors named "Bhavin K Patel"
Article Synopsis
- - Mastering manual small-incision cataract surgery (MSICS) is challenging for beginner surgeons, particularly in creating a proper scleral tunnel and making keratome entries.
- - Many surgeons experience issues like premature entry and iris prolapse, often due to improper techniques, with premature entry being more associated with crescent blade tunnel construction.
- - The novel trypan blue dye-assisted tunnel staining (TBTS) technique aids in clear tunnel visualization, potentially decreasing the risk of premature entry when using a keratome.
Targeted delivery of mannosylated-PLGA nanoparticles of antiretroviral drug to brain.
Int J Nanomedicine
August 2018
Mannosylated polymeric nanoparticles (NPs) enable improvement of brain bioavailability and reduction of dosing due to efficient drug delivery at the target site. Mannose receptors are present on the surface of macrophages, and therefore, in this study, it is expected that mannosylated NPs of anti-human immunodeficiency virus drug may target the macrophages, which may improve the therapeutic outcome and reduce the toxicity of antiretroviral bioactives. Poly(lactic-co-glycolic acid) (PLGA) and mannosylated-PLGA NPs (Mn-PLGA NPs) were prepared and administered by intravenous route in a dose of 10 mg/kg.
View Article and Find Full Text PDFFixed dose combination containing beclomethasone dipropionate (BDP) and formoterol fumarate dihydrate (FFD) is used in the treatment of asthma in form of dry powder inhaler. Two methods are described for the simultaneous determination of BDP and FFD in commercial rotacap formulation. The first method was based on HPTLC separation of the two drugs followed by densitometric measurements of their spots at 220 nm.
View Article and Find Full Text PDFChemometrics-assisted UV spectrophotometric and RP-HPLC methods are presented for the simultaneous determination of tolperisone hydrochloride (TOL) and diclofenac sodium (DIC) from their combined pharmaceutical dosage form. Chemometric methods are based on principal component regression and partial least-square regression models. Two sets of standard mixtures, calibration sets, and validation sets were prepared.
View Article and Find Full Text PDFObjective. The main objective of the present investigation was to develop and optimize oral sustained release Chitosan nanoparticles (CNs) of rifampicin by design of experiment (DOE). Methodology.
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