Synopsis of recent research by authors named "Bhaval Parmar"
- Bhaval Parmar's recent research focuses on the role of Cyclooxygenase-2 (COX-2) in embryonic development, particularly in cardiac and craniofacial patterning in chick embryos, highlighting its significance in regulating critical cellular processes and development stages.
- Studies revealed that inhibition of COX-2 using etoricoxib leads to various developmental anomalies, including abnormal cardiac looping and cranial feature malformations, by affecting the expression of important cell adhesion molecules and factors involved in cranial neural crest cell migration.
- Parmar's findings emphasize the essential functions of COX-2 and the prostanoid PGE in early embryogenesis, with analyses showing that COX-2 inhibition results in severe structural defects such as anophthalmia and phocomelia, thereby underlining the necessity of COX-2 in proper developmental processes.
