Formulation development and evaluation of medicated chewing gum of anti-emetic drug.

Context: Medicated chewing gum (MCG) of Domperidone Maleate (DM) was developed by direct compression method with the goal to achieve quick onset of action and to improve patient compliance.

Objective: Formulation development of MCG of DM and optimization of the formulation by screening of different excipients.

Material And Methods: MCG containing DM was prepared by screening different concentrations of sweeteners, flavouring agents, softening agents, lubricants and anti-adherents by changing one variable at a time.